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Literature summary extracted from

  • Gratraud, P.; Huws, E.; Falkard, B.; Adjalley, S.; Fidock, D.A.; Berry, L.; Jacobs, W.R.; Baird, M.S.; Vial, H.; Kremer, L.
    Oleic acid biosynthesis in Plasmodium falciparum: Characterization of the stearoyl-CoA desaturase and investigation as a potential therapeutic target (2009), PLoS ONE, 4, e6889.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.19.1 methyl 8-methoxy-8-(2-octylcycloprop-1-en-1-yl)octanoate
-
 Plasmodium falciparum
1.14.19.1 methyl 9-(2-octylcycloprop-1-en-1-yl)nonanoate
-
 Plasmodium falciparum
1.14.19.1 methyl malvalate
-
 Plasmodium falciparum
1.14.19.1 methyl sterculate inhibits the synthesis of oleic acid both with parasite lysates and infected erythrocytes, most likely by targeting SCD Plasmodium falciparum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.19.1 0.0566
-
 stearoyl-CoA in 0.1 M potassium phosphate buffer pH 7.2, at 37°C Plasmodium falciparum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.19.1 endoplasmic reticulum
-
 Plasmodium falciparum 5783
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.19.1 114000
-
 calculated from amino acid sequence Plasmodium falciparum

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.1 Plasmodium falciparum Q8I0W9
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.1 schizont
-
 Plasmodium falciparum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.1 stearoyl-CoA + NADPH + H+ + O2
-
 Plasmodium falciparum oleoyl-CoA + NADP+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.1 SCD
-
 Plasmodium falciparum
1.14.19.1 stearoyl-CoA desaturase
-
 Plasmodium falciparum

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.1 cytochrome b5
-
 Plasmodium falciparum
1.14.19.1 NADPH SCD is mainly dependent on NADPH, no oleic acid is produced in the absence of NADPH Plasmodium falciparum

pI Value

EC Number Organism Comment pI Value Maximum pI Value
1.14.19.1 Plasmodium falciparum calculated from amino acid sequence
-
 9.2

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.19.1 0.041
-
 in 0.1 M potassium phosphate buffer pH 7.2, at 37°C Plasmodium falciparum methyl 8-methoxy-8-(2-octylcycloprop-1-en-1-yl)octanoate
1.14.19.1 0.08
-
 in 0.1 M potassium phosphate buffer pH 7.2, at 37°C Plasmodium falciparum methyl 9-(2-octylcycloprop-1-en-1-yl)nonanoate
1.14.19.1 0.087
-
 in 0.1 M potassium phosphate buffer pH 7.2, at 37°C Plasmodium falciparum methyl sterculate
1.14.19.1 0.167
-
 in 0.1 M potassium phosphate buffer pH 7.2, at 37°C Plasmodium falciparum methyl malvalate

Expression

EC Number Organism Comment Expression
1.14.19.1 Plasmodium falciparum there is a 53fold increase of SCD transcript expression level between 18 and 36 h during the late trophozoite stage up