BRENDA - Enzyme Database

Distribution, regulation and role of the agmatine deiminase system in mutans streptococci

Griswold, A.R.; Nascimento, M.M.; Burne, R.A.; Oral Microbiol. Immunol. 24, 79-82 (2009)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
3.5.3.12
agmatine
-
Streptococcus criceti
3.5.3.12
agmatine
-
Streptococcus downei
3.5.3.12
agmatine
-
Streptococcus mutans
3.5.3.12
agmatine
-
Streptococcus ratti
3.5.3.12
agmatine
-
Streptococcus sobrinus
Application
EC Number
Application
Commentary
Organism
3.5.3.12
medicine
remove of dental plaque biofilms
Streptococcus criceti
3.5.3.12
medicine
remove of dental plaque biofilms
Streptococcus downei
3.5.3.12
medicine
remove of dental plaque biofilms
Streptococcus mutans
3.5.3.12
medicine
remove of dental plaque biofilms
Streptococcus ratti
3.5.3.12
medicine
remove of dental plaque biofilms
Streptococcus sobrinus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.5.3.12
carbohydrate
-
Streptococcus mutans
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.5.3.12
no activity in Streptococcus gordonii
-
-
-
3.5.3.12
no activity in Streptococcus sanguinis
-
genospecies 1
-
3.5.3.12
Streptococcus criceti
-
-
-
3.5.3.12
Streptococcus criceti AHT
-
-
-
3.5.3.12
Streptococcus downei
-
-
-
3.5.3.12
Streptococcus downei 33748
-
-
-
3.5.3.12
Streptococcus mutans
-
strain UA159 and strain GS-5
-
3.5.3.12
Streptococcus oralis
-
-
-
3.5.3.12
Streptococcus ratti
-
strain FA-1 and strain BHT
-
3.5.3.12
Streptococcus salivarius
-
-
-
3.5.3.12
Streptococcus sanguinis
-
genospecies 2
-
3.5.3.12
Streptococcus sobrinus
-
-
-
3.5.3.12
Streptococcus sobrinus 6715
-
-
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
3.5.3.12
0.0002
-
strain FA-1, 25 mM glucose, without agmatine
Streptococcus ratti
3.5.3.12
0.004
-
strain FA-1, 25 mM galactose, without agmatine
Streptococcus ratti
3.5.3.12
0.006
-
25 mM glucose + 10 mM agmatine
Streptococcus downei
3.5.3.12
0.0097
-
25 mM sorbitol + 10 mM agmatine
Streptococcus sobrinus
3.5.3.12
0.0109
-
25 mM sorbitol + 10 mM agmatine
Streptococcus criceti
3.5.3.12
0.016
-
25 mM glucose + 10 mM agmatine
Streptococcus sobrinus
3.5.3.12
0.02
-
strain FA-1, 250 mM glucose, without agmatine
Streptococcus ratti
3.5.3.12
0.03
-
strain FA-1, 250 mM glucose + 10 mM agmatine
Streptococcus ratti
3.5.3.12
0.032
-
strain FA-1, 25 mM glucose + 10 mM agmatine
Streptococcus ratti
3.5.3.12
0.034
-
strain FA-1, 25 mM galactose + 10 mM agmatine
Streptococcus ratti
3.5.3.12
0.04
-
strain FA-1, 250 mM galactose, without agmatine
Streptococcus ratti
3.5.3.12
0.052
-
strain BHT, 25 mM glucose + 10 mM agmatine
Streptococcus ratti
3.5.3.12
0.058
-
strain UA159, 25 mM glucose + 10 mM agmatine
Streptococcus mutans
3.5.3.12
0.058
-
strain FA-1, 250 mM galactose + 10 mM agmatine
Streptococcus ratti
3.5.3.12
0.078
-
strain GS-5, 25 mM galactose + 10 mM agmatine
Streptococcus mutans
3.5.3.12
0.102
-
strain FA-1, 25 mM glucose + 10 mM agmatine
Streptococcus ratti
3.5.3.12
0.17
-
strain UA159, 25 mM sorbitol + 10 mM agmatine
Streptococcus mutans
3.5.3.12
0.4762
-
strain UA159, 25 mM galactose + 10 mM agmatine
Streptococcus mutans
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.5.3.12
agmatine + H2O
assay at pH 6.0, 30 min, reaction terminated by adding 10% trichloracetic acid
700535
Streptococcus sanguinis
NH3 + N-carbamoylputrescine
-
-
-
?
3.5.3.12
agmatine + H2O
assay at pH 6.0, 30 min, reaction terminated by adding 10% trichloracetic acid
700535
Streptococcus ratti
NH3 + N-carbamoylputrescine
-
-
-
?
3.5.3.12
agmatine + H2O
assay at pH 6.0, 30 min, reaction terminated by adding 10% trichloracetic acid
700535
Streptococcus mutans
NH3 + N-carbamoylputrescine
-
-
-
?
3.5.3.12
agmatine + H2O
assay at pH 6.0, 30 min, reaction terminated by adding 10% trichloracetic acid
700535
Streptococcus salivarius
NH3 + N-carbamoylputrescine
-
-
-
?
3.5.3.12
agmatine + H2O
assay at pH 6.0, 30 min, reaction terminated by adding 10% trichloracetic acid
700535
Streptococcus oralis
NH3 + N-carbamoylputrescine
-
-
-
?
3.5.3.12
agmatine + H2O
assay at pH 6.0, 30 min, reaction terminated by adding 10% trichloracetic acid
700535
Streptococcus sobrinus
NH3 + N-carbamoylputrescine
-
-
-
?
3.5.3.12
agmatine + H2O
assay at pH 6.0, 30 min, reaction terminated by adding 10% trichloracetic acid
700535
Streptococcus criceti
NH3 + N-carbamoylputrescine
-
-
-
?
3.5.3.12
agmatine + H2O
assay at pH 6.0, 30 min, reaction terminated by adding 10% trichloracetic acid
700535
Streptococcus downei
NH3 + N-carbamoylputrescine
-
-
-
?
3.5.3.12
agmatine + H2O
assay at pH 6.0, 30 min, reaction terminated by adding 10% trichloracetic acid
700535
Streptococcus criceti AHT
NH3 + N-carbamoylputrescine
-
-
-
?
3.5.3.12
agmatine + H2O
assay at pH 6.0, 30 min, reaction terminated by adding 10% trichloracetic acid
700535
Streptococcus sobrinus 6715
NH3 + N-carbamoylputrescine
-
-
-
?
3.5.3.12
agmatine + H2O
assay at pH 6.0, 30 min, reaction terminated by adding 10% trichloracetic acid
700535
Streptococcus downei 33748
NH3 + N-carbamoylputrescine
-
-
-
?
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
3.5.3.12
additional information
-
assay at pH 6.0, 30 min, reaction stopped by 10% trichloroacetic acid
Streptococcus sanguinis
3.5.3.12
6
-
assay at
Streptococcus criceti
3.5.3.12
6
-
assay at
Streptococcus downei
3.5.3.12
6
-
assay at
Streptococcus mutans
3.5.3.12
6
-
assay at
Streptococcus oralis
3.5.3.12
6
-
assay at
Streptococcus ratti
3.5.3.12
6
-
assay at
Streptococcus salivarius
3.5.3.12
6
-
assay at
Streptococcus sobrinus
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
3.5.3.12
agmatine
-
Streptococcus criceti
3.5.3.12
agmatine
-
Streptococcus downei
3.5.3.12
agmatine
-
Streptococcus mutans
3.5.3.12
agmatine
-
Streptococcus ratti
3.5.3.12
agmatine
-
Streptococcus sobrinus
Application (protein specific)
EC Number
Application
Commentary
Organism
3.5.3.12
medicine
remove of dental plaque biofilms
Streptococcus criceti
3.5.3.12
medicine
remove of dental plaque biofilms
Streptococcus downei
3.5.3.12
medicine
remove of dental plaque biofilms
Streptococcus mutans
3.5.3.12
medicine
remove of dental plaque biofilms
Streptococcus ratti
3.5.3.12
medicine
remove of dental plaque biofilms
Streptococcus sobrinus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.5.3.12
carbohydrate
-
Streptococcus mutans
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
3.5.3.12
0.0002
-
strain FA-1, 25 mM glucose, without agmatine
Streptococcus ratti
3.5.3.12
0.004
-
strain FA-1, 25 mM galactose, without agmatine
Streptococcus ratti
3.5.3.12
0.006
-
25 mM glucose + 10 mM agmatine
Streptococcus downei
3.5.3.12
0.0097
-
25 mM sorbitol + 10 mM agmatine
Streptococcus sobrinus
3.5.3.12
0.0109
-
25 mM sorbitol + 10 mM agmatine
Streptococcus criceti
3.5.3.12
0.016
-
25 mM glucose + 10 mM agmatine
Streptococcus sobrinus
3.5.3.12
0.02
-
strain FA-1, 250 mM glucose, without agmatine
Streptococcus ratti
3.5.3.12
0.03
-
strain FA-1, 250 mM glucose + 10 mM agmatine
Streptococcus ratti
3.5.3.12
0.032
-
strain FA-1, 25 mM glucose + 10 mM agmatine
Streptococcus ratti
3.5.3.12
0.034
-
strain FA-1, 25 mM galactose + 10 mM agmatine
Streptococcus ratti
3.5.3.12
0.04
-
strain FA-1, 250 mM galactose, without agmatine
Streptococcus ratti
3.5.3.12
0.052
-
strain BHT, 25 mM glucose + 10 mM agmatine
Streptococcus ratti
3.5.3.12
0.058
-
strain UA159, 25 mM glucose + 10 mM agmatine
Streptococcus mutans
3.5.3.12
0.058
-
strain FA-1, 250 mM galactose + 10 mM agmatine
Streptococcus ratti
3.5.3.12
0.078
-
strain GS-5, 25 mM galactose + 10 mM agmatine
Streptococcus mutans
3.5.3.12
0.102
-
strain FA-1, 25 mM glucose + 10 mM agmatine
Streptococcus ratti
3.5.3.12
0.17
-
strain UA159, 25 mM sorbitol + 10 mM agmatine
Streptococcus mutans
3.5.3.12
0.4762
-
strain UA159, 25 mM galactose + 10 mM agmatine
Streptococcus mutans
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.5.3.12
agmatine + H2O
assay at pH 6.0, 30 min, reaction terminated by adding 10% trichloracetic acid
700535
Streptococcus sanguinis
NH3 + N-carbamoylputrescine
-
-
-
?
3.5.3.12
agmatine + H2O
assay at pH 6.0, 30 min, reaction terminated by adding 10% trichloracetic acid
700535
Streptococcus ratti
NH3 + N-carbamoylputrescine
-
-
-
?
3.5.3.12
agmatine + H2O
assay at pH 6.0, 30 min, reaction terminated by adding 10% trichloracetic acid
700535
Streptococcus mutans
NH3 + N-carbamoylputrescine
-
-
-
?
3.5.3.12
agmatine + H2O
assay at pH 6.0, 30 min, reaction terminated by adding 10% trichloracetic acid
700535
Streptococcus salivarius
NH3 + N-carbamoylputrescine
-
-
-
?
3.5.3.12
agmatine + H2O
assay at pH 6.0, 30 min, reaction terminated by adding 10% trichloracetic acid
700535
Streptococcus oralis
NH3 + N-carbamoylputrescine
-
-
-
?
3.5.3.12
agmatine + H2O
assay at pH 6.0, 30 min, reaction terminated by adding 10% trichloracetic acid
700535
Streptococcus sobrinus
NH3 + N-carbamoylputrescine
-
-
-
?
3.5.3.12
agmatine + H2O
assay at pH 6.0, 30 min, reaction terminated by adding 10% trichloracetic acid
700535
Streptococcus criceti
NH3 + N-carbamoylputrescine
-
-
-
?
3.5.3.12
agmatine + H2O
assay at pH 6.0, 30 min, reaction terminated by adding 10% trichloracetic acid
700535
Streptococcus downei
NH3 + N-carbamoylputrescine
-
-
-
?
3.5.3.12
agmatine + H2O
assay at pH 6.0, 30 min, reaction terminated by adding 10% trichloracetic acid
700535
Streptococcus criceti AHT
NH3 + N-carbamoylputrescine
-
-
-
?
3.5.3.12
agmatine + H2O
assay at pH 6.0, 30 min, reaction terminated by adding 10% trichloracetic acid
700535
Streptococcus sobrinus 6715
NH3 + N-carbamoylputrescine
-
-
-
?
3.5.3.12
agmatine + H2O
assay at pH 6.0, 30 min, reaction terminated by adding 10% trichloracetic acid
700535
Streptococcus downei 33748
NH3 + N-carbamoylputrescine
-
-
-
?
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
3.5.3.12
additional information
-
assay at pH 6.0, 30 min, reaction stopped by 10% trichloroacetic acid
Streptococcus sanguinis
3.5.3.12
6
-
assay at
Streptococcus criceti
3.5.3.12
6
-
assay at
Streptococcus downei
3.5.3.12
6
-
assay at
Streptococcus mutans
3.5.3.12
6
-
assay at
Streptococcus oralis
3.5.3.12
6
-
assay at
Streptococcus ratti
3.5.3.12
6
-
assay at
Streptococcus salivarius
3.5.3.12
6
-
assay at
Streptococcus sobrinus