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Literature summary extracted from
- Protein cysteine sulfinic acid reductase (sulfiredoxin) as a regulator of cell proliferation and drug response (2008), Oncogene, 27, 4877-4887.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.8.98.2 | medicine | increased sulfiredoxin has been linked with oncogenic transformation, data support a role for Srx in controlling the phosphorylation status of key regulatory kinases | Homo sapiens |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.8.98.2 | into the vector pcDNA3 | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.98.2 | peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + R-SH | Homo sapiens | - |
peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.98.2 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.8.98.2 | A-549 cell | - |
Homo sapiens | - |
| 1.8.98.2 | HEK-293 cell | - |
Homo sapiens | - |
| 1.8.98.2 | MCF-7 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.98.2 | additional information | promotes the reversal of cysteine modified PTP1B to its reduced and enzymatically active form | Homo sapiens | ? | - |
? | |
| 1.8.98.2 | additional information | reduction of cysteine sulfinic acid to sulfenic acid in proteins subject to oxidative stress | Homo sapiens | ? | - |
? | |
| 1.8.98.2 | peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + R-SH | - |
Homo sapiens | peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.8.98.2 | protein cysteine sulfinic acid reductase | - |
Homo sapiens |
| 1.8.98.2 | Srx | - |
Homo sapiens |
| 1.8.98.2 | sulfiredoxin | - |
Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.98.2 | ATP | - |
Homo sapiens | |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 1.8.98.2 | Homo sapiens | oxidative stress and growth factors can markedly upregulate Srx transcript and protein levels | up |
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Release 2023.1 (January 2023)
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