BRENDA - Enzyme Database

Protein cysteine sulfinic acid reductase (sulfiredoxin) as a regulator of cell proliferation and drug response

Lei, K.; Townsend, D.M.; Tew, K.D.; Oncogene 27, 4877-4887 (2008)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
1.8.98.2
medicine
increased sulfiredoxin has been linked with oncogenic transformation, data support a role for Srx in controlling the phosphorylation status of key regulatory kinases
Homo sapiens
Cloned(Commentary)
EC Number
Commentary
Organism
1.8.98.2
into the vector pcDNA3
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.8.98.2
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + R-SH
Homo sapiens
-
peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.8.98.2
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.8.98.2
A-549 cell
-
Homo sapiens
-
1.8.98.2
HEK-293 cell
-
Homo sapiens
-
1.8.98.2
MCF-7 cell
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.8.98.2
additional information
promotes the reversal of cysteine modified PTP1B to its reduced and enzymatically active form
700520
Homo sapiens
?
-
-
-
-
1.8.98.2
additional information
reduction of cysteine sulfinic acid to sulfenic acid in proteins subject to oxidative stress
700520
Homo sapiens
?
-
-
-
-
1.8.98.2
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + R-SH
-
700520
Homo sapiens
peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.8.98.2
ATP
-
Homo sapiens
Application (protein specific)
EC Number
Application
Commentary
Organism
1.8.98.2
medicine
increased sulfiredoxin has been linked with oncogenic transformation, data support a role for Srx in controlling the phosphorylation status of key regulatory kinases
Homo sapiens
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
1.8.98.2
into the vector pcDNA3
Homo sapiens
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.8.98.2
ATP
-
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.8.98.2
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + R-SH
Homo sapiens
-
peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.8.98.2
A-549 cell
-
Homo sapiens
-
1.8.98.2
HEK-293 cell
-
Homo sapiens
-
1.8.98.2
MCF-7 cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.8.98.2
additional information
promotes the reversal of cysteine modified PTP1B to its reduced and enzymatically active form
700520
Homo sapiens
?
-
-
-
-
1.8.98.2
additional information
reduction of cysteine sulfinic acid to sulfenic acid in proteins subject to oxidative stress
700520
Homo sapiens
?
-
-
-
-
1.8.98.2
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + R-SH
-
700520
Homo sapiens
peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
-
-
?
Expression
EC Number
Organism
Commentary
Expression
1.8.98.2
Homo sapiens
oxidative stress and growth factors can markedly upregulate Srx transcript and protein levels
up
Expression (protein specific)
EC Number
Organism
Commentary
Expression
1.8.98.2
Homo sapiens
oxidative stress and growth factors can markedly upregulate Srx transcript and protein levels
up