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Literature summary extracted from

  • Zuendorf, G.; Kahlert, S.; Bunik, V.I.; Reiser, G.
    alpha-Ketoglutarate dehydrogenase contributes to production of reactive oxygen species in glutamate-stimulated hippocampal neurons in situ (2009), Neuroscience, 158, 610-616.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.105 succinyl phosphonate specific inhibitor of cellular KGDHC, 20% inhibition at 0.2 mM Rattus norvegicus
1.2.1.105 succinyl phosphonate triethyl ester specific inhibitor of cellular KGDHC, 44% inhibition at 0.5 mM Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.105 mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.105 additional information Rattus norvegicus KGDHC contributes to neuronal reactive oxygen species increase in situ ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.105 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.105 hippocampus
-
 Rattus norvegicus
-
1.2.1.105 neuron hippocampal neuron Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.105 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
-
 Rattus norvegicus [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
 ?
1.2.1.105 additional information KGDHC contributes to neuronal reactive oxygen species increase in situ Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.105 alpha-ketoglutarate dehydrogenase complex
-
 Rattus norvegicus
1.2.1.105 KGDHC
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.105 NAD+
-
 Rattus norvegicus
1.2.1.105 thiamine diphosphate
-
 Rattus norvegicus