Literature summary extracted from

Pushparajah, D.S.; Umachandran, M.; Plant, K.E.; Plant, N.; Ioannides, C.
Differential response of human and rat epoxide hydrolase to polycyclic aromatic hydrocarbon exposure: studies using precision-cut tissue slices (2008), Mutat. Res., 640, 153-161.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.3.2.9	additional information	benzo[a]pyrene, dibenzo[a,h]anthracene and fluoranthene give rise to a statistically significant increase in epoxide hydrolase activity, which is accompanied by a concomitant increase in epoxide hydrolase protein levels, dibenzo[a,l]pyrene, benzo[b]fluoranthene and 1-methylphenanthrene, influence neither activity nor enzyme protein levels	Homo sapiens
3.3.2.9	additional information	benzo[a]pyrene, dibenzo[a,h]anthracene and fluoranthene give rise to a statistically significant increase in epoxide hydrolase activity, which is accompanied by a concomitant increase in epoxide hydrolase protein levels, dibenzo[a,l]pyrene, benzo[b]fluoranthene and 1-methylphenanthrene, influence neither activity nor enzyme protein levels	Rattus norvegicus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.3.2.9	microsome	-	Homo sapiens	-	-
3.3.2.9	microsome	-	Rattus norvegicus	-	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.3.2.9	Homo sapiens	-	-	-
3.3.2.9	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.3.2.9	liver	-	Homo sapiens	-
3.3.2.9	liver	-	Rattus norvegicus	-
3.3.2.9	lung	in the rat basal lung epoxide hydrolase activity is much lower than liver	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.3.2.9	benzo[a]pyrene 5-oxide + H2O	-	Homo sapiens	?	-	?
3.3.2.9	benzo[a]pyrene 5-oxide + H2O	-	Rattus norvegicus	?	-	?
3.3.2.9	cis-stilbene oxide + H2O	-	Homo sapiens	(1R,2R)-1,2-diphenylethane-1,2-diol	-	?
3.3.2.9	cis-stilbene oxide + H2O	-	Rattus norvegicus	(1R,2R)-1,2-diphenylethane-1,2-diol	-	?

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Release 2023.1 (January 2023)