Literature summary extracted from

Antonella Fai, A.F.; Corda, M.; Era, B.; Fadda, M.; Matos, M.; Quezada, E.; Santana, L.; Picciau, C.; Podda, G.; Delogu, G.
Tyrosinase inhibitor activity of coumarin-resveratrol hybrids (2009), Molecules, 14, 2514-2520.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.14.18.1	3-(3',4',5'-trihydroxyphenyl)-6,8-dihydroxycoumarin	potent, non-competitive tyrosinase inhibitor, 68.3% inhibition at 0.8 mM	Agaricus bisporus
1.14.18.1	3-(3-hydroxyphenyl)-2H-chromen-2-one	19.3% inhibition at 0.8 mM	Agaricus bisporus
1.14.18.1	6-hydroxy-3-(4'-hydroxyphenyl)coumarin	26.7% inhibition at 0.8 mM	Agaricus bisporus
1.14.18.1	7-hydroxy-3-(4-hydroxyphenyl)-2H-chromen-2-one	9.6% inhibition at 0.8 mM	Agaricus bisporus
1.14.18.1	umbelliferone	-	Agaricus bisporus

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.18.1	Agaricus bisporus	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.18.1	L-DOPA + O2	-	Agaricus bisporus	dopaquinone + H2O	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.14.18.1	tyrosinase	-	Agaricus bisporus

IC50 Value

EC Number	IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
1.14.18.1	0.1	-	IC50 above 0.1 mM, in 0.067 M phosphoric acid buffer (pH 6.8), at 25°C	Agaricus bisporus	7-hydroxy-3-(4-hydroxyphenyl)-2H-chromen-2-one
1.14.18.1	0.27	-	in 0.067 M phosphoric acid buffer (pH 6.8), at 25°C	Agaricus bisporus	3-(3',4',5'-trihydroxyphenyl)-6,8-dihydroxycoumarin
1.14.18.1	0.42	-	in 0.067 M phosphoric acid buffer (pH 6.8), at 25°C	Agaricus bisporus	umbelliferone
1.14.18.1	1.567	-	in 0.067 M phosphoric acid buffer (pH 6.8), at 25°C	Agaricus bisporus	6-hydroxy-3-(4'-hydroxyphenyl)coumarin
1.14.18.1	3.68	-	in 0.067 M phosphoric acid buffer (pH 6.8), at 25°C	Agaricus bisporus	3-(3-hydroxyphenyl)-2H-chromen-2-one

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Release 2023.1 (January 2023)