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Literature summary extracted from
- The neurobiology of D-amino acid oxidase and its involvement in schizophrenia (2009), Mol. Psychiatry, 15, 122-137.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.4.3.3 | additional information | the enzyme activity is increased in schizophrenia | Homo sapiens |
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.4.3.3 | medicine | the enzyme inhibition might have an therapeutic effect in schizophrenia treatment | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.4.3.3 | D-serine + H2O + O2 | Homo sapiens | metabolizaation of the N-methyl D-aspartate receptor co-agonist | 2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.4.3.3 | Homo sapiens | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 1.4.3.3 | flavoprotein | - |
Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.4.3.3 | D-serine + H2O + O2 | - |
Homo sapiens | 2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? | |
| 1.4.3.3 | D-serine + H2O + O2 | metabolizaation of the N-methyl D-aspartate receptor co-agonist | Homo sapiens | 2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.4.3.3 | DAO | - |
Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.4.3.3 | FAD | flavoenzyme | Homo sapiens | |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 1.4.3.3 | Homo sapiens | enzyme expression is increased in schizophrenia | up |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.4.3.3 | physiological function | the enzyme modulates the function of the N-methyl D-aspartate receptor contributing to the involvement of the receptor signalling in schizophrenia | Homo sapiens |
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Release 2023.1 (January 2023)
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