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Literature summary extracted from

  • Alfano, R.W.; Leppla, S.H.; Liu, S.; Bugge, T.H.; Meininger, C.J.; Lairmore, T.C.; Mulne, A.F.; Davis, S.H.; Duesbery, N.S.; Frankel, A.E.
    Matrix metalloproteinase-activated anthrax lethal toxin inhibits endothelial invasion and neovasculature formation during in vitro morphogenesis (2009), Mol. Cancer Res., 7, 452-461.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.4.24.83 medicine engineered lethal anthrax toxin prevents tumor growth by inhibiting angiogenesis (10 nmol/l engineered protective antigen + 5.5 nmol/l lethal factor) Bacillus anthracis

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.83 additional information non-specific furin cleavage sequence (164RKKR167) of the protective antigen of anthrax toxin is substituted by the cleavage sequence for gelatinase class of matrix metalloproteinase (164GPLGMLSQ171) to prevent non-specific action and enhance target specific action in endothelial cells Bacillus anthracis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.83 additional information Bacillus anthracis anthrax lethal factor cleaves and inactivates extracellular signal-regulated kinase kinases of the mitogen-activated protein kinase pathway in human dermal microvascular endothelial cells ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.83 Bacillus anthracis
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-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.83 additional information anthrax lethal factor cleaves and inactivates extracellular signal-regulated kinase kinases of the mitogen-activated protein kinase pathway in human dermal microvascular endothelial cells Bacillus anthracis ?
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 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.83 anthrax lethal toxin
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 Bacillus anthracis