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Literature summary extracted from

  • Niwa, S.; Graf, C.; Bornancin, F.
    Ceramide kinase deficiency impairs microendothelial cell angiogenesis in vitro (2009), Microvasc. Res., 77, 389-393.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.138 NVP-231 potent inhibition of ceramide kinase catalyzed production of ceramide 1-phosphate both in vitro and in cell-based assays Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.138 ATP + ceramide Mus musculus
-
 ADP + ceramide 1-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.138 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.138 dermal microvascular endothelial cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.138 ATP + ceramide
-
 Mus musculus ADP + ceramide 1-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.138 ceramide kinase
-
 Mus musculus
2.7.1.138 CERK
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.7.1.138 malfunction capillary-like tube formation is significantly impaired in CerK-deficient cells or in wild type cells treated with NVP-231 as compared with untreated wild type cells, ceramide kinase ablation increases serum ceramide levels at the expense of dihydroceramide levels without affecting sphingosine, dihydrosphingosine, sphingosine-1-phosphate or dihydrosphingosine-1-phosphate levels, in both Cerk -/- and NVP-231-treated cells, the density of the cell monolayer area is in increased at the expense of the tube forming area Mus musculus
2.7.1.138 physiological function ceramide kinase catalyzed formation of ceramide 1-phosphate may regulate angiogenesis by a novel mechanism that is independent of sphingosine-1-phosphate formation and signaling Mus musculus