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Literature summary extracted from

  • Rawat, M.; Kovacevic, S.; Billman-Jacobe, H.; Av-Gay, Y.
    Inactivation of mshB, a key gene in the mycothiol biosynthesis pathway in Mycobacterium smegmatis (2003), Microbiology, 149, 1341-1349.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.103 additional information Mycolicibacterium smegmatis MshB activity as a control point regulating mycothiol production ?
-
 ?
3.5.1.103 additional information Mycolicibacterium smegmatis mc(2)155 / ATCC 700084 MshB activity as a control point regulating mycothiol production ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.103 Mycolicibacterium smegmatis
-
-
-
3.5.1.103 Mycolicibacterium smegmatis A0R2I7
-
-
3.5.1.103 Mycolicibacterium smegmatis mc(2)155 / ATCC 700084 A0R2I7
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.103 additional information MshB activity as a control point regulating mycothiol production Mycolicibacterium smegmatis ?
-
 ?
3.5.1.103 additional information MshB activity as a control point regulating mycothiol production Mycolicibacterium smegmatis mc(2)155 / ATCC 700084 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.103 MshB
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 Mycolicibacterium smegmatis

General Information

EC Number General Information Comment Organism
3.5.1.103 malfunction disruption of mshB in Mycobacterium smegmatis results in decreased production of mycothiol (5–10% of the parent strain mc2155) but does not abolish mycothiol synthesis completely. Complementation of the MshB2 mutants with the mshB gene results in increased mycothiol production towards the exponential and stationary phases of the bacterial growth cycle. The results suggest that another enzyme is capable of mycothiol biosynthesis by providing N-acetylglucosaminylinositol deacetylation activity in the absence of MshB Mycolicibacterium smegmatis