Literature summary extracted from

Demaude, J.; Leveque, M.; Chaumaz, G.; Eutamene, H.; Fioramonti, J.; Bueno, L.; Ferrier, L.
Acute stress increases colonic paracellular permeability in mice through a mast cell-independent mechanism: Involvement of pancreatic trypsin (2009), Life Sci., 84, 847-852.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.4.21.4	additional information	colonic trypsin activity increases during acute stress	Mus musculus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.21.4	atropine	strongly diminishes trypsin activity in stressed animals	Mus musculus
3.4.21.4	Soybean trypsin inhibitor	-	Mus musculus

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.4	Mus musculus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.21.4	colon	-	Mus musculus	-
3.4.21.4	pancreas	-	Mus musculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.21.4	N-alpha-benzoyl-L-Arg-4-nitroanilide + H2O	-	Mus musculus	N-alpha-benzoyl-L-Arg + 4-nitroaniline	-	?

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Release 2023.1 (January 2023)