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Literature summary extracted from

  • Smith, S.M.; Uslaner, J.M.; Yao, L.; Mullins, C.M.; Surles, N.O.; Huszar, S.L.; McNaughton, C.H.; Pascarella, D.M.; Kandebo, M.; Hinchliffe, R.M.; Sparey, T.; Brandon, N.J.; Jones, B.; Venkatraman, S.; Young, M.B.; Sachs, N.; Jacobson, M.A.; Hutson, P.H.
    The behavioral and neurochemical effects of a novel D-amino acid oxidase inhibitor compound 8 [4H-thieno [3,2-b]pyrrole-5-carboxylic acid] and D-serine (2009), J. Pharmacol. Exp. Ther., 328, 921-930.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.4.3.3 expression in CHO cells Homo sapiens
1.4.3.3 expression in CHO cells Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.3 4H-thieno [3,2-b]pyrrole-5-carboxylic acid i.e. compound 8, a moderately potent inhibitor of human DAAO in vitro Homo sapiens
1.4.3.3 4H-thieno [3,2-b]pyrrole-5-carboxylic acid i.e. compound 8, a moderately potent inhibitor of rat DAAO in vitro, inhibits DAAO activity in kideny by 96% and in brain by 80% resulting in a significant elevation in both plasma and cerebrospinal fluid D-serine concentration. Compound 8 fails to significantly influence amphetamine-induced psychomotor activity, nucleus accumbens dopamine release, or a dizocilpine maleate-induced deficit in novel object recognition in rats Rattus norvegicus
1.4.3.3 5-methyl-1H-pyrazole-3-carboxylic acid
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.3.3 D-alanine + H2O + O2 Homo sapiens
-
 pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-alanine + H2O + O2 Rattus norvegicus
-
 pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-serine + H2O + O2 Homo sapiens
-
 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?
1.4.3.3 D-serine + H2O + O2 Rattus norvegicus high doses of D-serine attenuate both amphetamine-induced psychomotor activity and dopamine release and also improve performance in novel object recognition 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.3 Homo sapiens
-
-
-
1.4.3.3 Rattus norvegicus
-
 male Wistar rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.3 brain cerebellum and cortex Rattus norvegicus
-
1.4.3.3 kidney
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.3 D-alanine + H2O + O2
-
 Homo sapiens pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-alanine + H2O + O2
-
 Rattus norvegicus pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-serine + H2O + O2
-
 Homo sapiens 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?
1.4.3.3 D-serine + H2O + O2
-
 Rattus norvegicus 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?
1.4.3.3 D-serine + H2O + O2 high doses of D-serine attenuate both amphetamine-induced psychomotor activity and dopamine release and also improve performance in novel object recognition Rattus norvegicus 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.3 DAAO
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.4.3.3 37
-
 assay at Homo sapiens
1.4.3.3 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.4.3.3 8.2
-
 assay at Homo sapiens
1.4.3.3 8.2
-
 assay at Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.4.3.3 0.000114
-
-
 Rattus norvegicus 4H-thieno [3,2-b]pyrrole-5-carboxylic acid
1.4.3.3 0.000145
-
-
 Homo sapiens 4H-thieno [3,2-b]pyrrole-5-carboxylic acid