EC Number | Cloned (Comment) | Organism |
---|---|---|
7.6.2.2 | gene MDR1, expression of wild-type and mutant MDR1571A enzymes in HEK-293 cells. MDR1 571 genotypes in leukemia patients, overview | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
7.6.2.2 | G571A/G191R | a naturally occuring mutant, the genetic variation modulates cancer drug resistance and efflux transport, minimal effect on doxorubicin and daunorubicin, the MDR1-dependent resistance on vinblastine, vincristine, paclitaxel, and etoposide is reduced by approximately 5fold, overview | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
7.6.2.2 | membrane | - |
Homo sapiens | 16020 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
7.6.2.2 | Mg2+ | - |
Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
7.6.2.2 | ATP + H2O + xenobiotic/in | Homo sapiens | - |
ADP + phosphate + xenobiotic/out | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
7.6.2.2 | Homo sapiens | P08183 | human multidrug resistance gene MDR1 encoding a membrane-bound transporter P-glycoprotein | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
7.6.2.2 | additional information | - |
- |
Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
7.6.2.2 | ATP + H2O + daunorubicin/in | - |
Homo sapiens | ADP + phosphate + daunorubicin/out | - |
? | |
7.6.2.2 | ATP + H2O + doxorubicin/in | - |
Homo sapiens | ADP + phosphate + doxorubicin/out | - |
? | |
7.6.2.2 | ATP + H2O + etoposide/in | - |
Homo sapiens | ADP + phosphate + etoposide/out | - |
? | |
7.6.2.2 | ATP + H2O + paclitaxel/in | - |
Homo sapiens | ADP + phosphate + paclitaxel/out | - |
? | |
7.6.2.2 | ATP + H2O + rhodamine 123/in | - |
Homo sapiens | ADP + phosphate + rhodamine 123/out | - |
? | |
7.6.2.2 | ATP + H2O + vinblastine sulfate/in | - |
Homo sapiens | ADP + phosphate + vinblastine sulfate/out | - |
? | |
7.6.2.2 | ATP + H2O + vincristine sulfate/in | - |
Homo sapiens | ADP + phosphate + vincristine sulfate/out | - |
? | |
7.6.2.2 | ATP + H2O + VP-16/in | - |
Homo sapiens | ADP + phosphate + VP-16/out | - |
? | |
7.6.2.2 | ATP + H2O + xenobiotic/in | - |
Homo sapiens | ADP + phosphate + xenobiotic/out | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
7.6.2.2 | MDR1 | - |
Homo sapiens |
7.6.2.2 | P-glycoprotein | - |
Homo sapiens |
7.6.2.2 | Pgp | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
7.6.2.2 | ATP | - |
Homo sapiens |