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Literature summary extracted from

  • Jung, H.A.; Yoon, N.Y.; Kang, S.S.; Kim, Y.S.; Choi, J.S.
    Inhibitory activities of prenylated flavonoids from Sophora flavescens against aldose reductase and generation of advanced glycation endproducts (2008), J. Pharm. Pharmacol., 60, 1227-1236.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.21
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.21 (2S)-2'-methoxykurarinone potent inhibitor of rat lens aldose reductase Rattus norvegicus
1.1.1.21 (2S)-3beta,7,4'-trihydroxy-5-methoxy-8-(gamma,gamma-dimethylallyl)-flavanone
-
 Homo sapiens
1.1.1.21 (2S)-3beta,7,4'-trihydroxy-5-methoxy-8-(gamma,gamma-dimethylallyl)-flavanone
-
 Rattus norvegicus
1.1.1.21 (2S)-7,4'-dihydroxy-5-methoxy-8-(gamma,gamma-dimethylallyl)-flavanone potent inhibitor of recombinant human aldose reductase Homo sapiens
1.1.1.21 8-lavandulylkaempferol potent inhibitor of recombinant human aldose reductase Homo sapiens
1.1.1.21 8-lavandulylkaempferol potent inhibitor of rat lens aldose reductase Rattus norvegicus
1.1.1.21 desmethylanhydroicaritin potent inhibitor of recombinant human aldose reductase Homo sapiens
1.1.1.21 desmethylanhydroicaritin potent inhibitor of rat lens aldose reductase Rattus norvegicus
1.1.1.21 epalrestat
-
 Homo sapiens
1.1.1.21 kuraridin potent inhibitor of recombinant human aldose reductase Homo sapiens
1.1.1.21 kurarinol potent inhibitor of rat lens aldose reductase Rattus norvegicus
1.1.1.21 kurarinone potent inhibitor of rat lens aldose reductase Rattus norvegicus
1.1.1.21 kushenol E potent inhibitor of recombinant human aldose reductase Homo sapiens
1.1.1.21 kushenol E potent inhibitor of rat lens aldose reductase Rattus norvegicus
1.1.1.21 quercetin potent inhibitor of recombinant human aldose reductase Homo sapiens
1.1.1.21 quercetin potent inhibitor of rat lens aldose reductase Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.21 Homo sapiens
-
-
-
1.1.1.21 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.21 lens
-
 Rattus norvegicus
-

Synonyms

EC Number Synonyms Comment Organism
1.1.1.21 aldose reductase
-
 Homo sapiens
1.1.1.21 aldose reductase
-
 Rattus norvegicus
1.1.1.21 RLAR
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.21 0.00027
-
-
 Homo sapiens kuraridin
1.1.1.21 0.00028
-
-
 Homo sapiens epalrestat
1.1.1.21 0.00037
-
-
 Homo sapiens (2S)-7,4'-dihydroxy-5-methoxy-8-(gamma,gamma-dimethylallyl)-flavanone
1.1.1.21 0.00045
-
-
 Homo sapiens desmethylanhydroicaritin
1.1.1.21 0.00079
-
-
 Homo sapiens 8-lavandulylkaempferol
1.1.1.21 0.00085
-
-
 Homo sapiens kushenol E
1.1.1.21 0.00095
-
-
 Rattus norvegicus desmethylanhydroicaritin
1.1.1.21 0.00213
-
-
 Rattus norvegicus kurarinol
1.1.1.21 0.00254
-
-
 Homo sapiens quercetin
1.1.1.21 0.00299
-
-
 Rattus norvegicus kurarinone
1.1.1.21 0.00363
-
-
 Rattus norvegicus (2S)-3beta,7,4'-trihydroxy-5-methoxy-8-(gamma,gamma-dimethylallyl)-flavanone
1.1.1.21 0.00377
-
-
 Rattus norvegicus (2S)-2'-methoxykurarinone
1.1.1.21 0.0038
-
-
 Rattus norvegicus 8-lavandulylkaempferol
1.1.1.21 0.00773
-
-
 Rattus norvegicus quercetin
1.1.1.21 0.00774
-
-
 Rattus norvegicus kushenol E