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Literature summary extracted from

  • Anderson, S.; Carreiro, S.; Quenzer, T.; Gale, D.; Xiang, C.; Gukasyan, H.; Lafontaine, J.; Cheng, H.; Krauss, A.; Prasanna, G.
    In vivo evaluation of 11beta-hydroxysteroid dehydrogenase activity in the rabbit eye (2009), J. Ocul. Pharmacol. Ther., 25, 215-222.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.146 carbenoxolone potent and selective 11beta-HSD1 inhibitor Oryctolagus cuniculus
1.1.1.146 PF-3319913 potent and selective 11beta-HSD1 inhibitor, a 1% dose of PF-3319913 inhibits in vivo 11beta-HSD1 enzyme activity in the rabbit eye by 100% at 2 h Oryctolagus cuniculus
1.1.1.146 PF-3859622 potent and selective 11beta-HSD1 inhibitor, a 2% dose of PF-3859622 consistently inhibits in vivo 11beta-HSD1 enzyme activity in the rabbit eye by 100% at 6 and 12 h, a 0.2% dose of PF-3859622 causes 81% inhibition of cortisone conversion at 6 h Oryctolagus cuniculus
1.1.1.146 PF-904955 potent and selective 11beta-HSD1 inhibitor, a 1% dose of PF-904955 inhibits in vivo 11beta-HSD1 enzyme activity in the rabbit eye by 88% at 2 h Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.146 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.146 eye 11beta-HSD1 is widely expressed in the eye, particularly ciliary epithelium Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.146 cortisol + NADP+
-
 Oryctolagus cuniculus cortisone + NADPH
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.146 11beta-HSD1
-
 Oryctolagus cuniculus
1.1.1.146 11beta-hydroxysteroid dehydrogenase-1
-
 Oryctolagus cuniculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.146 NADP+
-
 Oryctolagus cuniculus