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Literature summary extracted from

  • Kim, I.H.; Park, S.K.; Hong, S.T.; Jo, Y.S.; Kim, E.J.; Park, E.H.; Han, S.B.; Shin, H.S.; Sun, W.; Kim, H.T.; Soderling, S.H.; Kim, H.
    Inositol 1,4,5-trisphosphate 3-kinase a functions as a scaffold for synaptic Rac signaling (2009), J. Neurosci., 29, 14039-14049.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.127 additional information enhanced inositol 1,4,5-trisphosphate 3-kinase A in the synaptic field by long-term potentiation induction in rat hippocampal neurons Mus musculus
2.7.1.127 additional information enhanced IP3K-A IR in the synaptic field by long-term potentiation induction in rat hippocampal neurons Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.127 generation of knock-out mice Mus musculus
2.7.1.127 generation of knock-out rats and point mutant, IP3K-A is overexpressed in DIV 22 hippocampal neurons by infection with adenovirus containing full-length IP3K-A Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.127 K262A the green fluorescent protein-inositol 1,4,5-trisphosphate 3-kinase A point mutant is generated by site-directed mutagenesis, point mutant lacks kinase activity Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.127 Ca2+ IP3K-A catalytic activity regulates calcium levels by modulating the metabolism of 1D-myo-inositol 1,4,5-trisphosphate Mus musculus
2.7.1.127 Ca2+ IP3K-A catalytic activity regulates calcium levels by modulating the metabolism of 1D-myo-inositol 1,4,5-trisphosphate Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate Mus musculus reducing the influx of calcium released from endoplasmic reticulum via IP3 receptor signaling ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate Rattus norvegicus reducing the influx of calcium released from endoplasmic reticulum via IP3 receptor signaling ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.127 Mus musculus
-
-
-
2.7.1.127 Rattus norvegicus P17105
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.127 brain
-
 Mus musculus
-
2.7.1.127 dendritic cell
-
 Mus musculus
-
2.7.1.127 hippocampal cell line
-
 Rattus norvegicus
-
2.7.1.127 neuron
-
 Mus musculus
-
2.7.1.127 neuron
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate reducing the influx of calcium released from endoplasmic reticulum via IP3 receptor signaling Mus musculus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate reducing the influx of calcium released from endoplasmic reticulum via IP3 receptor signaling Rattus norvegicus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.127 inositol 1,4,5-trisphosphate 3-kinase A
-
 Mus musculus
2.7.1.127 inositol 1,4,5-trisphosphate 3-kinase A
-
 Rattus norvegicus
2.7.1.127 IP3K-A
-
 Mus musculus
2.7.1.127 IP3K-A
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
2.7.1.127 Rattus norvegicus overexpression of IP3K-A in DIV 22 hippocampal neurons by infection with adenovirus containing full-length inositol 1,4,5-trisphosphate 3-kinase A leads to a markedly increased number of dendritic structure 18 h after infection, overexpressed GFP-IP3K-A signals are highly localized in the heads of dendritic protrusions additional information

General Information

EC Number General Information Comment Organism
2.7.1.127 malfunction enzyme knock-out mice show deficits of synaptic plasticity in perforant path and in hippocampal-dependent memory performances Mus musculus
2.7.1.127 physiological function on neural activation, inositol 1,4,5-trisphosphate 3-kinase A binds directly to activated Rac1 and recruits it to the actin cytoskeleton in the postsynaptic area, enzyme is critical for the spatial and temporal regulation of spine actin remodeling, synaptic plasticity, and learning and memory via an activity-dependent Rac scaffolding mechanism, inositol 1,4,5-trisphosphate 3-kinase A catalytic activity regulates calcium levels by modulating the metabolism of 1D-myo-inositol 1,4,5-trisphosphate Mus musculus
2.7.1.127 physiological function on neural activation, inositol 1,4,5-trisphosphate 3-kinase A binds directly to activated Rac1 and recruits it to the actin cytoskeleton in the postsynaptic area, enzyme is critical for the spatial and temporal regulation of spine actin remodeling, synaptic plasticity, and learning and memory via an activity-dependent Rac scaffolding mechanism, inositol 1,4,5-trisphosphate 3-kinase A catalytic activity regulates calcium levels by modulating the metabolism of 1D-myo-inositol 1,4,5-trisphosphate Rattus norvegicus