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Literature summary extracted from

  • Schlicker, C.; Hall, R.A.; Vullo, D.; Middelhaufe, S.; Gertz, M.; Supuran, C.T.; Muehlschlegel, F.A.; Steegborn, C.
    Structure and inhibition of the CO2-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans (2009), J. Mol. Biol., 385, 1207-1220.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.2.1.1 Can2 in complex with acetate, hanging drop vapour diffusion method Cryptococcus neoformans

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.1 3-bromo-4-amino-benzenesulfonamide
-
 Cryptococcus neoformans
4.2.1.1 3-chloro-4-amino-benzenesulfonamide
-
 Cryptococcus neoformans
4.2.1.1 3-fluoro-4-amino-benzenesulfonamide
-
 Cryptococcus neoformans
4.2.1.1 3-iodo-4-amino-benzenesulfonamide
-
 Cryptococcus neoformans
4.2.1.1 4-(2-amino-pyrimidin-4-yl)-benzenesulfonamide
-
 Cryptococcus neoformans
4.2.1.1 4-(4-sulfanilyl-aminoethyl)-benzenesulfonamide
-
 Cryptococcus neoformans
4.2.1.1 4-(4-sulfanilyl-aminomethyl)-benzenesulfonamide
-
 Cryptococcus neoformans
4.2.1.1 4-(carboxyethyl)-benzenesulfonamide
-
 Cryptococcus neoformans
4.2.1.1 4-amino-6-chloro-benzene-1,3-disulfonamide
-
 Cryptococcus neoformans
4.2.1.1 4-amino-6-trifluoromethyl-benzene-1,3-disulfonamide
-
 Cryptococcus neoformans
4.2.1.1 4-amino-benzenesulfonamide
-
 Cryptococcus neoformans
4.2.1.1 4-aminoethyl-benzenesulfonamide
-
 Cryptococcus neoformans
4.2.1.1 4-aminomethyl-benzenesulfonamide
-
 Cryptococcus neoformans
4.2.1.1 4-carboxy-benzenesulfonamide
-
 Cryptococcus neoformans
4.2.1.1 4-hydroxyethyl-benzenesulfonamide
-
 Cryptococcus neoformans
4.2.1.1 4-hydroxymethyl-benzenesulfonamide
-
 Cryptococcus neoformans
4.2.1.1 4-methyl-5-imino-1,3,4-thiadiazoline-2-sulfonamide
-
 Cryptococcus neoformans
4.2.1.1 4-methyl-benzenesulfonamide
-
 Cryptococcus neoformans
4.2.1.1 5-amino-1,3,4-thiadiazole-2-sulfonamide
-
 Cryptococcus neoformans
4.2.1.1 acetate
-
 Cryptococcus neoformans
4.2.1.1 aminobenzolamide
-
 Cryptococcus neoformans
4.2.1.1 benzolamide
-
 Cryptococcus neoformans
4.2.1.1 brinzolamide
-
 Cryptococcus neoformans
4.2.1.1 celecoxib
-
 Cryptococcus neoformans
4.2.1.1 chlorazolamide
-
 Cryptococcus neoformans
4.2.1.1 dichlorophenamide
-
 Cryptococcus neoformans
4.2.1.1 dorzolamide
-
 Cryptococcus neoformans
4.2.1.1 ethoxzolamide
-
 Cryptococcus neoformans
4.2.1.1 indisulam
-
 Cryptococcus neoformans
4.2.1.1 methazolamide
-
 Cryptococcus neoformans
4.2.1.1 N-(5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl)acetamide
-
 Cryptococcus neoformans
4.2.1.1 saccharin
-
 Cryptococcus neoformans
4.2.1.1 sulpiride
-
 Cryptococcus neoformans
4.2.1.1 sulthiame
-
 Cryptococcus neoformans
4.2.1.1 topiramate
-
 Cryptococcus neoformans
4.2.1.1 valdecoxib
-
 Cryptococcus neoformans
4.2.1.1 zonisamide
-
 Cryptococcus neoformans

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.2.1.1 Zn2+ contains one Zn2+ per monomer Cryptococcus neoformans

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.1 Cryptococcus neoformans
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.1 CO2 + H2O
-
 Cryptococcus neoformans H2CO3
-
 r

Subunits

EC Number Subunits Comment Organism
4.2.1.1 dimer x-ray crystallography Cryptococcus neoformans

Synonyms

EC Number Synonyms Comment Organism
4.2.1.1 Can2
-
 Cryptococcus neoformans
4.2.1.1 carbonic anhydrase
-
 Cryptococcus neoformans

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.2.1.1 0.0000105
-
 N-(5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl)acetamide at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.000023
-
 benzolamide at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.000042
-
 aminobenzolamide at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.000063
-
 methazolamide at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.000087
-
 ethoxzolamide at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.000087
-
 brinzolamide at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.0003
-
 4-amino-6-chloro-benzene-1,3-disulfonamide at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.000367
-
 topiramate at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.000379
-
 chlorazolamide at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.00044
-
 4-(carboxyethyl)-benzenesulfonamide at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.000484
-
 4-carboxy-benzenesulfonamide at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.000605
-
 3-chloro-4-amino-benzenesulfonamide at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.000623
-
 4-hydroxymethyl-benzenesulfonamide at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.000624
-
 4-(4-sulfanilyl-aminoethyl)-benzenesulfonamide at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.000704
-
 valdecoxib at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.000711
-
 3-iodo-4-amino-benzenesulfonamide at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.000765
-
 4-amino-benzenesulfonamide at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.000791
-
 5-amino-1,3,4-thiadiazole-2-sulfonamide at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.000809
-
 3-fluoro-4-amino-benzenesulfonamide at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.000812
-
 sulpiride at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.000815
-
 4-methyl-5-imino-1,3,4-thiadiazoline-2-sulfonamide at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.000878
-
 4-hydroxyethyl-benzenesulfonamide at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.00089
-
 sulthiame at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.000963
-
 indisulam at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.000968
-
 4-amino-6-trifluoromethyl-benzene-1,3-disulfonamide at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.000971
-
 zonisamide at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.000971
-
 4-(4-sulfanilyl-aminomethyl)-benzenesulfonamide at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.000977
-
 3-bromo-4-amino-benzenesulfonamide at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.00115
-
 4-methyl-benzenesulfonamide at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.001203
-
 dichlorophenamide at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.001394
-
 4-aminoethyl-benzenesulfonamide at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.003056
-
 celecoxib at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.003887
-
 4-(2-amino-pyrimidin-4-yl)-benzenesulfonamide at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.008347
-
 dorzolamide at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.01849
-
 4-aminomethyl-benzenesulfonamide at 20°C, pH 8.3 Cryptococcus neoformans
4.2.1.1 0.032
-
 saccharin at 20°C, pH 8.3 Cryptococcus neoformans