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Literature summary extracted from

  • Lee, S.J.; Park, W.H.; Park, S.D.; Moon, H.I.
    Aldose reductase inhibitors from Litchi chinensis Sonn (2009), J. Enzyme Inhib. Med. Chem., 24, 957-959.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.21 2,5-dihydrobenzoic acid
-
 Rattus norvegicus
1.1.1.21 D-mannitol
-
 Rattus norvegicus
1.1.1.21 delphinidin 3-O-beta-galactopyranoside most potent inhibitor Rattus norvegicus
1.1.1.21 delphinidin 3-O-beta-galactopyranoside-3',5'-di-O-beta-glucopyranoside
-
 Rattus norvegicus
1.1.1.21 additional information methanolic and ethanolic extracts of Litchi chinensis fruits are potent inhibitors of rat lens aldose reductase Rattus norvegicus
1.1.1.21 tetramethylene glutaric acid
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.21 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.21 lens
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.21 DL-glyceraldehyde + NADPH + H+
-
 Rattus norvegicus glycerol + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.21 aldose reductase
-
 Rattus norvegicus
1.1.1.21 ALR
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.21 NADPH
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.21 additional information
-
 D-mannitol IC50: above 0.1 mg/ml, 2,5-dihydrobenzoic acid IC50: 0.0359 mg/ml, delphinidin 3-O-beta-galactopyranoside-3',5'-di-O-beta-glucopyranoside IC50: 0.00123 mg/ml, delphinidin 3-O-beta-galactopyranoside IC50: 0.00023 mg/ml, methanolic and ethanolic extracts of Litchi chinensis fruits are potent inhibitors with IC50 values of 0.0036 and 0.0003 mg/ml, respectively Rattus norvegicus additional information