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Literature summary extracted from

  • Patel, N.; Iliadou, C.; Boonyapiwat, B.; Barlow, D.; Forbes, B.; Mitchell, S.; Steventon, G.
    Enzyme kinetic and molecular modelling studies of sulphur-containing substrates of phenylalanine 4-monooxygenase (2008), J. Enzyme Inhib. Med. Chem., 23, 958-963.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.16.1 L-methionine competitive inhibitor of the C-oxidation of L-phenylalanine Homo sapiens
1.14.16.1 L-methionine competitive inhibitor of the C-oxidation of L-phenylalanine Rattus norvegicus
1.14.16.1 S-carboxy-methyl-L-cysteine competitive inhibitor of the C-oxidation of L-phenylalanine Homo sapiens
1.14.16.1 S-carboxy-methyl-L-cysteine competitive inhibitor of the C-oxidation of L-phenylalanine Rattus norvegicus
1.14.16.1 S-methyl-ergothionine competitive inhibitor of the C-oxidation of L-phenylalanine Homo sapiens
1.14.16.1 S-methyl-ergothionine competitive inhibitor of the C-oxidation of L-phenylalanine Rattus norvegicus
1.14.16.1 S-methyl-L-cysteine competitive inhibitor of the C-oxidation of L-phenylalanine Homo sapiens
1.14.16.1 S-methyl-L-cysteine competitive inhibitor of the C-oxidation of L-phenylalanine Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.16.1 0.26
-
 L-phenylalanine at 37°C, 50 mM potassium phosphate buffer, pH 6.8 Rattus norvegicus
1.14.16.1 0.3
-
 S-methyl-ergothionine at 37°C, 50 mM potassium phosphate buffer, pH 6.8 Homo sapiens
1.14.16.1 0.45
-
 S-methyl-ergothionine at 37°C, 50 mM potassium phosphate buffer, pH 6.8 Rattus norvegicus
1.14.16.1 0.64
-
 L-phenylalanine at 37°C, 50 mM potassium phosphate buffer, pH 6.8 Homo sapiens
1.14.16.1 3.1
-
 L-methionine at 37°C, 50 mM potassium phosphate buffer, pH 6.8 Homo sapiens
1.14.16.1 4.6
-
 S-carboxy-methyl-L-cysteine at 37°C, 50 mM potassium phosphate buffer, pH 6.8 Homo sapiens
1.14.16.1 7.75
-
 L-methionine at 37°C, 50 mM potassium phosphate buffer, pH 6.8 Rattus norvegicus
1.14.16.1 14.73
-
 S-carboxy-methyl-L-cysteine at 37°C, 50 mM potassium phosphate buffer, pH 6.8 Rattus norvegicus
1.14.16.1 18.32
-
 S-methyl-L-cysteine at 37°C, 50 mM potassium phosphate buffer, pH 6.8 Homo sapiens
1.14.16.1 43.25
-
 S-methyl-L-cysteine at 37°C, 50 mM potassium phosphate buffer, pH 6.8 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.16.1 cytosol
-
 Homo sapiens 5829
-
1.14.16.1 cytosol
-
 Rattus norvegicus 5829
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.16.1 Homo sapiens
-
-
-
1.14.16.1 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.16.1 liver
-
 Homo sapiens
-
1.14.16.1 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.16.1 L-methionine + 5,6,7,8-tetrahydrobiopterin + O2
-
 Homo sapiens ?
-
 ?
1.14.16.1 L-methionine + 5,6,7,8-tetrahydrobiopterin + O2
-
 Rattus norvegicus ?
-
 ?
1.14.16.1 L-phenylalanine + 5,6,7,8-tetrahydrobiopterin + O2
-
 Homo sapiens L-tyrosine + 4a-hydroxytetrahydrobiopterin
-
 ?
1.14.16.1 L-phenylalanine + 5,6,7,8-tetrahydrobiopterin + O2
-
 Rattus norvegicus L-tyrosine + 4a-hydroxytetrahydrobiopterin
-
 ?
1.14.16.1 additional information the rate of clearance of the substrates via human PAH is L-phenylalanine > L-methionine > S-carboxy-methyl-L-cysteine > S-methyl-L-cysteine Homo sapiens ?
-
 ?
1.14.16.1 additional information the rate of clearance of the substrates via rat PAH is L-phenylalanine > L-methionine > S-carboxy-methyl-L-cysteine > S-methyl-L-cysteine Rattus norvegicus ?
-
 ?
1.14.16.1 S-carboxy-methyl-L-cysteine + 5,6,7,8-tetrahydrobiopterin + O2 poor substrate Homo sapiens S-carboxymethyl-L-cysteine S-oxide + dihydrobiopterin + H2O
-
 ?
1.14.16.1 S-carboxy-methyl-L-cysteine + 5,6,7,8-tetrahydrobiopterin + O2 poor substrate Rattus norvegicus S-carboxymethyl-L-cysteine S-oxide + dihydrobiopterin + H2O
-
 ?
1.14.16.1 S-methyl-ergothionine + 5,6,7,8-tetrahydrobiopterin + O2
-
 Homo sapiens ?
-
 ?
1.14.16.1 S-methyl-ergothionine + 5,6,7,8-tetrahydrobiopterin + O2
-
 Rattus norvegicus ?
-
 ?
1.14.16.1 S-methyl-L-cysteine + 5,6,7,8-tetrahydrobiopterin + O2 poor substrate Homo sapiens S-methyl-L-cysteine S-oxide + dihydrobiopterin + H2O
-
 ?
1.14.16.1 S-methyl-L-cysteine + 5,6,7,8-tetrahydrobiopterin + O2 poor substrate Rattus norvegicus S-methyl-L-cysteine S-oxide + dihydrobiopterin + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.16.1 PAH
-
 Homo sapiens
1.14.16.1 PAH
-
 Rattus norvegicus
1.14.16.1 phenylalanine hydroxylase
-
 Homo sapiens
1.14.16.1 phenylalanine hydroxylase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.16.1 5,6,7,8-tetrahydro-L-biopterin
-
 Homo sapiens
1.14.16.1 5,6,7,8-tetrahydro-L-biopterin
-
 Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.16.1 0.41
-
 S-methyl-ergothionine at 37°C, 50 mM potassium phosphate buffer, pH 6.8 Homo sapiens
1.14.16.1 0.5
-
 S-methyl-ergothionine at 37°C, 50 mM potassium phosphate buffer, pH 6.8 Rattus norvegicus
1.14.16.1 3.5
-
 L-methionine at 37°C, 50 mM potassium phosphate buffer, pH 6.8 Homo sapiens
1.14.16.1 5.01
-
 S-carboxy-methyl-L-cysteine at 37°C, 50 mM potassium phosphate buffer, pH 6.8 Homo sapiens
1.14.16.1 8.11
-
 L-methionine at 37°C, 50 mM potassium phosphate buffer, pH 6.8 Rattus norvegicus
1.14.16.1 13.14
-
 S-carboxy-methyl-L-cysteine at 37°C, 50 mM potassium phosphate buffer, pH 6.8 Rattus norvegicus
1.14.16.1 17.32
-
 S-methyl-L-cysteine at 37°C, 50 mM potassium phosphate buffer, pH 6.8 Homo sapiens
1.14.16.1 41.53
-
 S-methyl-L-cysteine at 37°C, 50 mM potassium phosphate buffer, pH 6.8 Rattus norvegicus