Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Lambertucci, R.H.; Hirabara, S.M.; Silveira, L.d.o.s..R.; Levada-Pires, A.C.; Curi, R.; Pithon-Curi, T.C.
    Palmitate increases superoxide production through mitochondrial electron transport chain and NADPH oxidase activity in skeletal muscle cells (2008), J. Cell. Physiol., 216, 796-804.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.6.5.10 additional information palmitic acid and antimycin A induce the enzyme and superoxide production Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.5.10 diphenylene iodonium inhibition of the NADPH oxidase complex activity reduces the increase of superoxide production induced by palmitic acid Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.6.5.10 cytoplasm NADPH oxidase complex consists of membrane and cytosolic subunits Rattus norvegicus 5737
-
1.6.5.10 membrane NADPH oxidase complex consists of membrane and cytosolic subunits. The gp91phox and p22phox are integral membrane proteins that form a heterodimeric flavocytochrome b558, the catalytic core of the enzyme Rattus norvegicus 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.6.5.10 NADPH + H+ + cytochrome c Rattus norvegicus
-
 NADP+ + reduced cytochrome c
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.6.5.10 Rattus norvegicus
-
 Wistar rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.5.10 skeletal muscle cell soleus, gastrocnemius, and quadriceps muscles, primary culture of cells Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.5.10 NADPH + H+ + cytochrome c
-
 Rattus norvegicus NADP+ + reduced cytochrome c
-
 ?

Subunits

EC Number Subunits Comment Organism
1.6.5.10 More NADPH oxidase complex consists of membrane and cytosolic subunits. The gp91phox and p22phox are integral membrane proteins that form a heterodimeric flavocytochrome b558, the catalytic core of the enzyme Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
1.6.5.10 NADPH oxidase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.6.5.10 cytochrome b558 gp91phox and p22phox are integral membrane proteins that form a heterodimeric flavocytochrome b558, the catalytic core of the enzyme Rattus norvegicus
1.6.5.10 cytochrome c
-
 Rattus norvegicus