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Literature summary extracted from

  • Buzza, M.S.; Dyson, J.M.; Choi, H.; Gardiner, E.E.; Andrews, R.K.; Kaiserman, D.; Mitchell, C.A.; Berndt, M.C.; Dong, J.F.; Bird, P.I.
    Antihemostatic activity of human granzyme B mediated by cleavage of von Willebrand factor (2008), J. Biol. Chem., 283, 22498-22504.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.79 additional information ristocetin does not increase granzyme B cleavage in the presence or absence of salt Homo sapiens

Application

EC Number Application Comment Organism
3.4.21.79 medicine extracellular granzyme B may help control localized coagulation during inflammation Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.79 S183A granzyme B active site mutant Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.79 additional information back salt progressively inhibits granzyme B-mediated von Willebrand factor cleavage Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.79 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.79 Fibrinogen + H2O granzyme B is unable to cleave soluble fibrinogen, granzyme B cleaves the matrix form at several sites Homo sapiens ?
-
 ?
3.4.21.79 additional information granzyme B has no effect on platelet adhesion and spreading on immobilized collagen. Granzyme B does not cleave glycocalicin (extracellular domain of GPIbalpha) Homo sapiens ?
-
 ?
3.4.21.79 von Willebrand factor + H2O granzyme B delays ristocetin-induced platelet aggregation and inhibits platelet adhesion and spreading on immobilized von Willebrand factor under static conditions. In vitro, granzyme B cannot cleave the von Willebrand factor conformer in solution, but cleavage is induced when von Willebrand factor is artificially unfolded or presented as a matrix. Granzyme B cleaves von Willebrand factor with comparable efficiency to proteinase ADAMTS-13 and rapidly processes ultra-large von Willebrand factor multimers released from activated endothelial cells under physiological shear. Granzyme B cleaves the A1 and A3 domains of von Willebrand factor Homo sapiens ?
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 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.79 GrB
-
 Homo sapiens