Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Babinski, K.J.; Kanjilal, S.J.; Raetz, C.R.
    Accumulation of the lipid A precursor UDP-2,3-diacylglucosamine in an Escherichia coli mutant lacking the lpxH gene (2002), J. Biol. Chem., 277, 25947-25956.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.54 UDP-2,3-bis((3R)-3-hydroxymyristoyl)alpha-D-glucosamine + H2O Escherichia coli a step of lipid A biosynthesis. LpxH is essential in Escherichia coli 2,3-bis((3R)-3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP
-
 ?
3.6.1.54 UDP-2,3-bis((3R)-3-hydroxymyristoyl)alpha-D-glucosamine + H2O Pseudomonas aeruginosa step of lipid A biosynthesis. Pseudomonas aeruginosa LpxH catalyzes UDP-2,3-diacylglucosamine hydrolysis in vitro and can substitute for Escherichia coli lpxH in vivo 2,3-bis((3R)-3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.54 Escherichia coli
-
-
-
3.6.1.54 Pseudomonas aeruginosa
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.54 UDP-2,3-bis((3R)-3-hydroxymyristoyl)alpha-D-glucosamine + H2O a step of lipid A biosynthesis. LpxH is essential in Escherichia coli Escherichia coli 2,3-bis((3R)-3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP
-
 ?
3.6.1.54 UDP-2,3-bis((3R)-3-hydroxymyristoyl)alpha-D-glucosamine + H2O step of lipid A biosynthesis. Pseudomonas aeruginosa LpxH catalyzes UDP-2,3-diacylglucosamine hydrolysis in vitro and can substitute for Escherichia coli lpxH in vivo Pseudomonas aeruginosa 2,3-bis((3R)-3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP
-
 ?
3.6.1.54 UDP-2,3-bis((3R)-3-hydroxymyristoyl)alpha-D-glucosamine + H2O Pseudomonas aeruginosa LpxH catalyzes UDP-2,3-diacylglucosamine hydrolysis in vitro and can substitute for Escherichia coli lpxH in vivo Pseudomonas aeruginosa 2,3-bis((3R)-3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.1.54 LpxH
-
 Escherichia coli
3.6.1.54 LpxH
-
 Pseudomonas aeruginosa

General Information

EC Number General Information Comment Organism
3.6.1.54 malfunction construction of Escherichia coli mutant KB21/pKJB5 that contains a kanamycin cassette inserted into the chromosomal copy of lpxH. The plasmid pKJB5 harbors lpxH+ and features a temperature-sensitive origin of replication. KB21/pKJB5 grows on nutrient medium at 30 °C but not at 44 °C when the plasmid carrying lpxH+ is lost. It is conclude that lpxH is essential in Escherichia coli Escherichia coli