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Literature summary extracted from

  • Kneidinger, B.; Graninger, M.; Puchberger, M.; Kosma, P.; Messner, P.
    Biosynthesis of nucleotide-activated D-glycero-D-manno-heptose (2001), J. Biol. Chem., 276, 20935-20944.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.168 overexpressed in Escherichia Aneurinibacillus thermoaerophilus
2.7.7.71
-
 Aneurinibacillus thermoaerophilus
5.3.1.28 overexpressed in Escherichia coli Aneurinibacillus thermoaerophilus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.3.1.28 21495
-
 x * 21495, calculated from sequence Aneurinibacillus thermoaerophilus
5.3.1.28 25000
-
 x * 25000, SDS-PAGE Aneurinibacillus thermoaerophilus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.168 D-glycero-alpha-D-manno-heptose 7-phosphate + ATP Aneurinibacillus thermoaerophilus enzyme is involved in biosynthesis of GDP-D-glycero-alpha-D-mannoheptose D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + ADP
-
 ?
2.7.7.71 D-glycero-D-alpha-manno-heptose 1-phosphate + GTP Aneurinibacillus thermoaerophilus the enzyme is involved in biosynthesis of GDP-D-glycero-D-manno-heptose, which is required for assembly of S-layer glycoprotein in Gram-positive bacteria GDP-D-glycero-D-alpha-manno-heptose + diphosphate
-
 ?
5.3.1.28 D-sedoheptulose 7-phosphate Aneurinibacillus thermoaerophilus the enzyme is involved in the biosynthesis of nucleotide-activated heptose D-glycero-D-manno-heptose 7-phosphate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.168 Aneurinibacillus thermoaerophilus Q9AGY8 DSM 10155
-
2.7.7.71 Aneurinibacillus thermoaerophilus Q9AGY6 DSM 10155
-
5.3.1.28 Aneurinibacillus thermoaerophilus Q9AGY7 DSM 10155
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.168
-
 Aneurinibacillus thermoaerophilus
2.7.7.71
-
 Aneurinibacillus thermoaerophilus
5.3.1.28
-
 Aneurinibacillus thermoaerophilus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.168 D-glycero-alpha-D-manno-heptose 7-phosphate + ATP
-
 Aneurinibacillus thermoaerophilus D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + ADP
-
 ?
2.7.1.168 D-glycero-alpha-D-manno-heptose 7-phosphate + ATP enzyme is involved in biosynthesis of GDP-D-glycero-alpha-D-mannoheptose Aneurinibacillus thermoaerophilus D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + ADP
-
 ?
2.7.7.71 D-glycero-D-alpha-manno-heptose 1-phosphate + GTP the enzyme is involved in biosynthesis of GDP-D-glycero-D-manno-heptose, which is required for assembly of S-layer glycoprotein in Gram-positive bacteria Aneurinibacillus thermoaerophilus GDP-D-glycero-D-alpha-manno-heptose + diphosphate
-
 ?
2.7.7.71 D-glycero-D-alpha-manno-heptose 1-phosphate + GTP no activity with ATP, CTP, dTTP or UTP Aneurinibacillus thermoaerophilus GDP-D-glycero-D-alpha-manno-heptose + diphosphate
-
 ?
5.3.1.28 D-sedoheptulose 7-phosphate
-
 Aneurinibacillus thermoaerophilus D-glycero-D-manno-heptose 7-phosphate
-
 r
5.3.1.28 D-sedoheptulose 7-phosphate the enzyme is involved in the biosynthesis of nucleotide-activated heptose Aneurinibacillus thermoaerophilus D-glycero-D-manno-heptose 7-phosphate
-
 r

Subunits

EC Number Subunits Comment Organism
5.3.1.28 ? x * 25000, SDS-PAGE Aneurinibacillus thermoaerophilus
5.3.1.28 ? x * 21495, calculated from sequence Aneurinibacillus thermoaerophilus

Synonyms

EC Number Synonyms Comment Organism
2.7.7.71 D,D-heptose 1-phosphate guanosyltransferase
-
 Aneurinibacillus thermoaerophilus
2.7.7.71 D-glycero-D-manno-heptose 1-phosphate guanosyltransferase
-
 Aneurinibacillus thermoaerophilus
5.3.1.28 sedoheptulose 7-phosphate isomerase
-
 Aneurinibacillus thermoaerophilus