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Literature summary extracted from

  • Kocer, S.S.; Matic, M.; Ingrassia, M.; Walker, S.G.; Roemer, E.; Licul, G.; Simon, S.R.
    Effects of anthrax lethal toxin on human primary keratinocytes (2008), J. Appl. Microbiol., 105, 1756-1767.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.24.83 molecular biology primary keratinocytes are resistant to LeTx cytotoxicity, and MEK cleavage does not correlate with LeTx cytotoxicity. LeTx is considered as an anti-inflammatory agent, however it upregulates RANTES Bacillus anthracis

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.83 additional information effects of anthrax lethal toxin on human primary keratinocytes are investigated. Cells are resistant to LeTx-triggered cytotoxicity, even though all the MEK (MEK1 through 7), except MEK5, are cleaved in these cells. Over the 24 h time course of the study, the levels of two pro-inflammatory molecules, interleukin-6 and granulocyte-macrophage colony stimulating factor (GM-CSF), decline, but the production of RANTES, a known chemoattractant for multiple types of immune cells, increases Bacillus anthracis

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.83 Bacillus anthracis
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Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.83 mitogen-activated protein kinase kinase 1 + H2O all but one of the mitogen-activated protein kinase kinases (MEK) are cleaved within 3 h, and the cleavage of MEKs in keratinocytes leads to their subsequent proteasome-mediated degradation at different rates Bacillus anthracis ?
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 ?
3.4.24.83 mitogen-activated protein kinase kinase 2 + H2O all but one of the mitogen-activated protein kinase kinases (MEK) are cleaved within 3 h, and the cleavage of MEKs in keratinocytes leads to their subsequent proteasome-mediated degradation at different rates Bacillus anthracis ?
-
 ?
3.4.24.83 mitogen-activated protein kinase kinase 3 + H2O all but one of the mitogen-activated protein kinase kinases (MEK) are cleaved within 3 h, and the cleavage of MEKs in keratinocytes leads to their subsequent proteasome-mediated degradation at different rates Bacillus anthracis ?
-
 ?
3.4.24.83 mitogen-activated protein kinase kinase 4 + H2O all but one of the mitogen-activated protein kinase kinases (MEK) are cleaved within 3 h, and the cleavage of MEKs in keratinocytes leads to their subsequent proteasome-mediated degradation at different rates Bacillus anthracis ?
-
 ?
3.4.24.83 mitogen-activated protein kinase kinase 6 + H2O all but one of the mitogen-activated protein kinase kinases (MEK) are cleaved within 3 h, and the cleavage of MEKs in keratinocytes leads to their subsequent proteasome-mediated degradation at different rates Bacillus anthracis ?
-
 ?
3.4.24.83 mitogen-activated protein kinase kinase 7 + H2O all but one of the mitogen-activated protein kinase kinases (MEK) are cleaved within 3 h, and the cleavage of MEKs in keratinocytes leads to their subsequent proteasome-mediated degradation at different rates Bacillus anthracis ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.83 anthrax lethal toxin
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 Bacillus anthracis
3.4.24.83 LeTx
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 Bacillus anthracis