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Literature summary extracted from

  • Munos, J.W.; Pu, X.; Mansoorabadi, S.O.; Kim, H.J.; Liu, H.W.
    A secondary kinetic isotope effect study of the 1-deoxy-D-xylulose-5-phosphate reductoisomerase-catalyzed reaction: evidence for a retroaldol-aldol rearrangement (2009), J. Am. Chem. Soc., 131, 2048-2049.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.267 synthetic construct
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.267 1-deoxy-D-xylulose 5-phosphate + NADPH
-
 synthetic construct ? + NADP+
-
 ?
1.1.1.267 1-deoxy-D-xylulose 5-phosphate + NADPH + H+
-
 synthetic construct 2-C-methyl-D-erythritol 4-phosphate + NADP+
-
 ?
1.1.1.267 additional information a retroaldol/aldol mechanism for the DXR catalyzed rearrangement of 1-deoxy-D-xylulose 5-phosphate to 2-C-methyl-D-erythritol 4-phosphate. DXR first cleaves the C3-C4 bond of 1-deoxy-D-xylulose 5-phosphate in a retroaldol manner to generate a three-carbon and a two-carbon phosphate bimolecular intermediate. These two species are then reunited by an aldol reaction to form a new C-C bond, yielding the same aldehyde intermediate methylerythrose phosphate. Subsequent reduction of methylerythrose phosphate by NADPH affords 2-C-methyl-D-erythritol 4-phosphate synthetic construct ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.267 DXP reductoisomerase
-
 synthetic construct
1.1.1.267 DXR
-
 synthetic construct
1.1.1.267 MEP synthase
-
 synthetic construct

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.267 13.2
-
 1-deoxy-D-xylulose 5-phosphate
-
 synthetic construct
1.1.1.267 13.7
-
 1-deoxy-D-xylulose 5-phosphate
-
 synthetic construct
1.1.1.267 16.1
-
 1-deoxy-D-xylulose 5-phosphate
-
 synthetic construct

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.267 NADPH dependent on synthetic construct