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Literature summary extracted from

  • Saiga, A.; Iwai, K.; Hayakawa, T.; Takahata, Y.; Kitamura, S.; Nishimura, T.; Morimatsu, F.
    Angiotensin I-converting enzyme-inhibitory peptides obtained from chicken collagen hydrolysate (2008), J. Agric. Food Chem., 56, 9586-9591.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.15.1 Gly-L-Ala-Hyp-Gly-L-Leu-Hyp-Gly-L-Pro highest ACE-inhibitory activity Oryctolagus cuniculus
3.4.15.1 Gly-L-Ala-Hyp-Gly-L-Leu-Hyp-Gly-L-Pro highest ACE-inhibitory activity Rattus norvegicus
3.4.15.1 Gly-L-Ala-Hyp-Gly-L-Pro-L-Ala-Gly-L-Pro-Gly-Gly-L-Ile-Hyp-Gly-L-Glu-L-Arg-Gly
-
 Oryctolagus cuniculus
3.4.15.1 Gly-L-Ala-Hyp-Gly-L-Pro-L-Ala-Gly-L-Pro-Gly-Gly-L-Ile-Hyp-Gly-L-Glu-L-Arg-Gly
-
 Rattus norvegicus
3.4.15.1 Gly-L-Ile-Hyp-Gly-L-Glu-L-Arg-Gly-L-Pro-L-Val-Gly-L-Pro-L-Ser-Gly
-
 Oryctolagus cuniculus
3.4.15.1 Gly-L-Ile-Hyp-Gly-L-Glu-L-Arg-Gly-L-Pro-L-Val-Gly-L-Pro-L-Ser-Gly
-
 Rattus norvegicus
3.4.15.1 Gly-L-Leu-Hyp-Gly-L-Ser-L-Arg-Gly-L-Glu-L-Arg-Gly-L-Leu-Hyp-Gly
-
 Oryctolagus cuniculus
3.4.15.1 Gly-L-Leu-Hyp-Gly-L-Ser-L-Arg-Gly-L-Glu-L-Arg-Gly-L-Leu-Hyp-Gly
-
 Rattus norvegicus
3.4.15.1 additional information chicken collagen hydrolysates possess ACE-inhibitory activities, chicken collagen hydrolysates inhibit about 30% of the activity of ACE, whereas further enzymatic treatment doubles their activities Oryctolagus cuniculus
3.4.15.1 additional information chicken collagen hydrolysates possess ACE-inhibitory activities, chicken collagen hydrolysates inhibit about 30% of the activity of ACE, whereas further enzymatic treatment doubles their activities Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.15.1 angiotensin I + H2O Rattus norvegicus
-
 angiotensin II + L-His-L-Leu
-
 ?
3.4.15.1 angiotensin I + H2O Oryctolagus cuniculus
-
 angiotensin II + L-His-L-Leu
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.15.1 Oryctolagus cuniculus
-
-
-
3.4.15.1 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.15.1 blood plasma
-
 Rattus norvegicus
-
3.4.15.1 lung
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.15.1 angiotensin I + H2O
-
 Rattus norvegicus angiotensin II + L-His-L-Leu
-
 ?
3.4.15.1 angiotensin I + H2O
-
 Oryctolagus cuniculus angiotensin II + L-His-L-Leu
-
 ?
3.4.15.1 hippuryl-L-His-L-Leu + H2O
-
 Rattus norvegicus hippuric acid + L-His-L-Leu
-
 ?
3.4.15.1 hippuryl-L-His-L-Leu + H2O
-
 Oryctolagus cuniculus hippuric acid + L-His-L-Leu
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.15.1 ACE
-
 Rattus norvegicus
3.4.15.1 ACE
-
 Oryctolagus cuniculus
3.4.15.1 angiotensin I-converting enzyme
-
 Rattus norvegicus
3.4.15.1 angiotensin I-converting enzyme
-
 Oryctolagus cuniculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.15.1 0.0294
-
 in 100 mM sodium borate buffer (pH 8.3), 500 mM NaCl, at 37°C Oryctolagus cuniculus Gly-L-Ala-Hyp-Gly-L-Leu-Hyp-Gly-L-Pro
3.4.15.1 0.0434
-
 in 100 mM sodium borate buffer (pH 8.3), 500 mM NaCl, at 37°C Oryctolagus cuniculus Gly-L-Ile-Hyp-Gly-L-Glu-L-Arg-Gly-L-Pro-L-Val-Gly-L-Pro-L-Ser-Gly
3.4.15.1 0.0456
-
 in 100 mM sodium borate buffer (pH 8.3), 500 mM NaCl, at 37°C Oryctolagus cuniculus Gly-L-Ala-Hyp-Gly-L-Pro-L-Ala-Gly-L-Pro-Gly-Gly-L-Ile-Hyp-Gly-L-Glu-L-Arg-Gly
3.4.15.1 0.0608
-
 in 100 mM sodium borate buffer (pH 8.3), 500 mM NaCl, at 37°C Oryctolagus cuniculus Gly-L-Leu-Hyp-Gly-L-Ser-L-Arg-Gly-L-Glu-L-Arg-Gly-L-Leu-Hyp-Gly