Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Cui, L.; Fan, Q.; Cui, L.; Miao, J.
    Histone lysine methyltransferases and demethylases in Plasmodium falciparum (2008), Int. J. Parasitol., 38, 1083-1097.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.11.27 gene MAL8P1.111, located on chromosome 8, DNA and amino acid sequence determination and analysis, detailed phylogenetic analysis, overview Plasmodium falciparum
1.14.11.27 gene PFF1440w, located on chromosome 6, DNA and amino acid sequence determination and analysis, detailed phylogenetic analysis, overview Plasmodium falciparum

Protein Variants

EC Number Protein Variants Comment Organism
1.14.11.27 additional information histone methyl-lysine marks display dynamic changes during the parasite asexual erythrocytic cycle, suggesting that they constitute an important epigenetic mechanism of gene regulation in malaria parasites Plasmodium falciparum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.27 additional information Plasmodium falciparum histone methyl-lysine marks display dynamic changes during the parasite asexual erythrocytic cycle, suggesting that they constitute an important epigenetic mechanism of gene regulation in malaria parasites ?
-
 ?
1.14.11.27 [histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2 Plasmodium falciparum predicted site-specificity from phylogenetic analysis [histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
1.14.11.27 [histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 Plasmodium falciparum predicted site-specificity from phylogenetic analysis [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.27 Plasmodium falciparum
-
 gene MAL8P1.111
-
1.14.11.27 Plasmodium falciparum
-
 gene PFF1440w
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.27 additional information histone methyl-lysine marks display dynamic changes during the parasite asexual erythrocytic cycle, suggesting that they constitute an important epigenetic mechanism of gene regulation in malaria parasites Plasmodium falciparum ?
-
 ?
1.14.11.27 additional information the enzyme also demethylates [histone H3]-N6,N6-dimethyl-L-lysine36 Plasmodium falciparum ?
-
 ?
1.14.11.27 additional information the enzymealso demethylates [histone H3]-N6,N6-dimethyl-L-lysine9 Plasmodium falciparum ?
-
 ?
1.14.11.27 [histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 3 2-oxoglutarate + 3 O2 predicted site-specificity from phylogenetic analysis Plasmodium falciparum [histone H3]-L-lysine4 + 3 succinate + 3 formaldehyde + 3 CO2
-
 ?
1.14.11.27 [histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2 predicted site-specificity from phylogenetic analysis Plasmodium falciparum [histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
1.14.11.27 [histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2 predicted site-specificity from phylogenetic analysis Plasmodium falciparum [histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
1.14.11.27 [histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 predicted site-specificity from phylogenetic analysis Plasmodium falciparum [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
1.14.11.27 [histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2 predicted site-specificity from phylogenetic analysis Plasmodium falciparum [histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.27 JMJD2A
-
 Plasmodium falciparum
1.14.11.27 More the enzyme belongs to large family of Jumonji C (JmjC)-domain-containing histone lysine demethylases, JHDMs Plasmodium falciparum
1.14.11.27 PfJmjC1
-
 Plasmodium falciparum
1.14.11.27 PfSET1
-
 Plasmodium falciparum
1.14.11.27 SET1
-
 Plasmodium falciparum

General Information

EC Number General Information Comment Organism
1.14.11.27 physiological function histone methyl-L-lysine marks display dynamic changes during the parasite asexual erythrocytic cycle, suggesting that they constitute an important epigenetic mechanism of gene regulation in malaria parasites Plasmodium falciparum
1.14.11.27 physiological function histone methyl-lysine marks display dynamic changes during the parasite asexual erythrocytic cycle, suggesting that they constitute an important epigenetic mechanism of gene regulation in malaria parasites Plasmodium falciparum