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Literature summary extracted from

  • Henriksen, P.A.; Sallenave, J.M.
    Human neutrophil elastase: mediator and therapeutic target in atherosclerosis (2008), Int. J. Biochem. Cell Biol., 40, 1095-1100.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.21.37 medicine neutrophil elastase is a mediator of atherosclerotic plaque development and a therapeutic target in atherosclerosis Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.37 alpha-1-antitrypsin
-
 Homo sapiens
3.4.21.37 elafin
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.37 additional information Homo sapiens human neutrophil elastase induces interleukin-8 release from HUVEC cells ?
-
 ?
3.4.21.37 plasminogen + H2O Homo sapiens
-
 miniplasminogen + ?
-
 ?
3.4.21.37 plasminogen activator inhibitor type-1 + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.37 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.37 atherosclerotic plaque
-
 Homo sapiens
-
3.4.21.37 HUVEC cell
-
 Homo sapiens
-
3.4.21.37 umbilical vein endothelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.37 additional information human neutrophil elastase induces interleukin-8 release from HUVEC cells Homo sapiens ?
-
 ?
3.4.21.37 plasminogen + H2O
-
 Homo sapiens miniplasminogen + ?
-
 ?
3.4.21.37 plasminogen activator inhibitor type-1 + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.37 neutrophil elastase
-
 Homo sapiens