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Literature summary extracted from
- The interaction of hydroxymandelate synthase with the 4-hydroxyphenylpyruvate dioxygenase inhibitor: NTBC (2008), Inorg. Chim. Acta, 361, 1197-1201.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.13.11.46 | 2-[2-nitro-4-(triflouromethyl)benzoyl]-1,3-cyclohexanedione | anaerobic conditions, complex with Fe2+ and enzyme, a herbicide/therapeutic that inhibits 4-hydroxyphenylpyruvate dioxygenase in a similar manner | Amycolatopsis orientalis |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.13.11.46 | 4-hydroxyphenylpyruvate + O2 | Amycolatopsis orientalis | alpha-keto acid dependent dioxygenase reaction | 4-hydroxymandelate + CO2 | substrate of non-ribosomal peptide antibiotics such as vancomycin and chloroeremomycin | ? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.13.11.46 | Amycolatopsis orientalis | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.13.11.46 | 4-hydroxyphenylpyruvate + O2 | alpha-keto acid dependent dioxygenase reaction | Amycolatopsis orientalis | 4-hydroxymandelate + CO2 | substrate of non-ribosomal peptide antibiotics such as vancomycin and chloroeremomycin | ? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.13.11.46 | HMS | - |
Amycolatopsis orientalis |
| 1.13.11.46 | hydroxymandelate synthase | - |
Amycolatopsis orientalis |
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