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Literature summary extracted from

  • Boitz, J.M.; Yates, P.A.; Kline, C.; Gaur, U.; Wilson, M.E.; Ullman, B.; Roberts, S.C.
    Leishmania donovani ornithine decarboxylase is indispensable for parasite survival in the mammalian host (2009), Infect. Immun., 77, 756-763.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
4.1.1.17 drug development pharmacological inhibition of ODC is a promising therapeutic paradigm for the treatment of visceral and perhaps other forms of leishmaniasis Leishmania donovani
4.1.1.17 pharmacology pharmacological inhibition of ODC is a promising therapeutic paradigm for the treatment of visceral and perhaps other forms of leishmaniasis Leishmania donovani

Protein Variants

EC Number Protein Variants Comment Organism
4.1.1.17 additional information construction of conditionally lethal DELTAodc null mutants by double targeted gene replacement within a virulent strain. Parasitemias of DELTAodc null mutants are reduced by 6 and 3 orders of magnitude, respectively, in livers and spleens of BALB/c mice showing compromised infectivity phenotypes, overview. Nutritional phenotypes and Survival of DELTAodc parasites in peritoneal macrophages, overview Leishmania donovani

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.17 alpha-difluoromethylornithine a suicide inhibitor of ODC, inhibits growth of wild-type Leishmania donovani amastigotes and effectively cures macrophages of parasites, thereby preventing host cell destruction Leishmania donovani

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.17 L-ornithine Leishmania donovani rate-limiting enzyme in polyamine biosynthesis. ODC is an essential cellular determinant necessary for the viability and growth of both Leishmania donovani promastigotes and amastigotes putrescine + CO2
-
 ?
4.1.1.17 L-ornithine Leishmania donovani LdBob rate-limiting enzyme in polyamine biosynthesis. ODC is an essential cellular determinant necessary for the viability and growth of both Leishmania donovani promastigotes and amastigotes putrescine + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.17 Leishmania donovani
-
-
-
4.1.1.17 Leishmania donovani LdBob
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.17 amastigote from livers and spleens of BALB/c mice Leishmania donovani
-
4.1.1.17 promastigote from livers and spleens of BALB/c mice Leishmania donovani
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.17 L-ornithine
-
 Leishmania donovani putrescine + CO2
-
 ?
4.1.1.17 L-ornithine rate-limiting enzyme in polyamine biosynthesis. ODC is an essential cellular determinant necessary for the viability and growth of both Leishmania donovani promastigotes and amastigotes Leishmania donovani putrescine + CO2
-
 ?
4.1.1.17 L-ornithine
-
 Leishmania donovani LdBob putrescine + CO2
-
 ?
4.1.1.17 L-ornithine rate-limiting enzyme in polyamine biosynthesis. ODC is an essential cellular determinant necessary for the viability and growth of both Leishmania donovani promastigotes and amastigotes Leishmania donovani LdBob putrescine + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.17 ODC
-
 Leishmania donovani