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Literature summary extracted from

  • Lacko, M.; Roelofs, H.M.; Te Morsche, R.H.; Voogd, A.C.; Oude Ophuis, M.B.; Peters, W.H.; Manni, J.J.
    Microsomal epoxide hydrolase genotypes and the risk for head and neck cancer (2008), Head Neck, 30, 836-844.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.3.2.9 medicine there is no risk-modifying effect of genetic polymorphisms in microsomal epoxide hydrolase on head and neck carcinogenesis, except for the predicted high activity variant H139R in patients with hypopharyngeal carcinoma Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.3.2.9 H139R the mutation enhances enzyme activity by approximately 25% Homo sapiens
3.3.2.9 Y113H the mutant is associated with 40-50% decrease in microsomal epoxide hydrolase activity Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.3.2.9 microsome
-
 Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.9 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.3.2.9 blood
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.9 cis-stilbene oxide + H2O
-
 Homo sapiens (1R,2R)-1,2-diphenylethane-1,2-diol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.3.2.9 mEH
-
 Homo sapiens