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Literature summary extracted from

  • Gaikwad, N.W.; Yang, L.; Rogan, E.G.; Cavalieri, E.L.
    Evidence for NQO2-mediated reduction of the carcinogenic estrogen ortho-quinones (2009), Free Radic. Biol. Med., 46, 253-262.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.10.5.1 medicine estrogen quinones, including estradiol estradiol-3,4-quinone, generated by estrogen metabolism, are thought to be responsible for estrogen-initiated carcinogenesis. NQO2 could be a novel target for prevention of breast cancer initiation Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.10.5.1 additional information melatonin has no effect Homo sapiens
1.10.5.1 quercetin
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.10.5.1 0.000033
-
 estradiol-3,4-quinone
-
 Homo sapiens
1.10.5.1 0.00075
-
 17beta-17-hydroxyestr-1(10)-ene-3,4-dione
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.10.5.1 additional information Homo sapiens NQO2 catalyzes the reduction of electrophilic estrogen quinones and thereby may act as a detoxification enzyme ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.10.5.1 Homo sapiens
-
 recombinant
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.10.5.1 1-benzyl-1,4-dihydronicotinamide + estradiol-3,4-quinone
-
 Homo sapiens 1-benzyl-3-carbamoylpyridinium + estrone-3,4-quinone
-
 r
1.10.5.1 17beta-17-hydroxyestr-1(10)-ene-3,4-dione + N-benzyldihydronicotinamide ping-pong mechanism, NQO2 is faster in reducing estrogen quinones than its homologue NQO1 Homo sapiens 17beta-estra-1(10),2,4-triene-3,4,17-triol + N-benzylnicotinamide
-
 ?
1.10.5.1 estrone-3,4-quinone + N-benzyldihydronicotinamide ping-pong mechanism, NQO2 is faster in reducing estrogen quinones than its homologue NQO1 Homo sapiens estrone-3,4-quinol + N-benzylnicotinamide
-
 ?
1.10.5.1 additional information NQO2 catalyzes the reduction of electrophilic estrogen quinones and thereby may act as a detoxification enzyme Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.10.5.1 MT3/NQO2
-
 Homo sapiens
1.10.5.1 NQO2
-
 Homo sapiens
1.10.5.1 NRH:quinone oxidoreductase 2
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.10.5.1 FAD
-
 Homo sapiens