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Literature summary extracted from

  • Fukiya, S.; Arata, M.; Kawashima, H.; Yoshida, D.; Kaneko, M.; Minamida, K.; Watanabe, J.; Ogura, Y.; Uchida, K.; Itoh, K.; Wada, M.; Ito, S.; Yokota, A.
    Conversion of cholic acid and chenodeoxycholic acid into their 7-oxo derivatives by Bacteroides intestinalis AM-1 isolated from human feces (2009), FEMS Microbiol. Lett., 293, 263-270.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.159 additional information activity is not induced by cholic acid, it is regulated in a growth phase-dependent manner Bacteroides fragilis
1.1.1.159 additional information activity is not induced by cholic acid, it is regulated in a growth phase-dependent manner Escherichia coli HB101
1.1.1.159 additional information activity is not induced by cholic acid, it is regulated in a growth phase-dependent manner. No NADP-dependent activity at either growth phase Bacteroides intestinalis
1.1.1.159 NAD+
-
 Bacteroides fragilis
1.1.1.159 NAD+
-
 Bacteroides intestinalis
1.1.1.159 NAD+
-
 Escherichia coli HB101

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.159 Bacteroides fragilis
-
 ATCC25285
-
1.1.1.159 Bacteroides fragilis NCTC 9343
-
 ATCC25285
-
1.1.1.159 Bacteroides intestinalis
-
 AM-1
-
1.1.1.159 Bacteroides intestinalis am-1
-
 AM-1
-
1.1.1.159 Escherichia coli HB101
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.159 chenodeoxycholic acid + NAD+
-
 Bacteroides fragilis 3alpha-hydroxy-7-oxo-5beta-cholan-24-oic acid + NADH
-
 ?
1.1.1.159 chenodeoxycholic acid + NAD+
-
 Bacteroides intestinalis 3alpha-hydroxy-7-oxo-5beta-cholan-24-oic acid + NADH
-
 ?
1.1.1.159 chenodeoxycholic acid + NAD+
-
 Escherichia coli HB101 3alpha-hydroxy-7-oxo-5beta-cholan-24-oic acid + NADH
-
 ?
1.1.1.159 chenodeoxycholic acid + NAD+
-
 Bacteroides fragilis NCTC 9343 3alpha-hydroxy-7-oxo-5beta-cholan-24-oic acid + NADH
-
 ?
1.1.1.159 chenodeoxycholic acid + NAD+
-
 Bacteroides intestinalis am-1 3alpha-hydroxy-7-oxo-5beta-cholan-24-oic acid + NADH
-
 ?
1.1.1.159 cholic acid + NAD+ in liquid culture, Bacteroides intestinalis AM-1 shows a relatively higher productivity than Escherichia coli HB101 and Bacteroides fragilis JCM11019T. Level of 7alpha-HSDH activity is higher in Bacteroides intestinalis AM-1 than in the other two strains Bacteroides fragilis 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholan-24-oic acid + NADH
-
 ?
1.1.1.159 cholic acid + NAD+ in liquid culture, Bacteroides intestinalis AM-1 shows a relatively higher productivity than Escherichia coli HB101 and Bacteroides fragilis JCM11019T. Level of 7alpha-HSDH activity is higher in Bacteroides intestinalis AM-1 than in the other two strains Bacteroides intestinalis 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholan-24-oic acid + NADH
-
 ?
1.1.1.159 cholic acid + NAD+ in liquid culture, Bacteroides intestinalis AM-1 shows a relatively higher productivity than Escherichia coli HB101 and Bacteroides fragilis JCM11019T. Level of 7alpha-HSDH activity is higher in Bacteroides intestinalis AM-1 than in the other two strains Escherichia coli HB101 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholan-24-oic acid + NADH
-
 ?
1.1.1.159 cholic acid + NAD+ in liquid culture, Bacteroides intestinalis AM-1 shows a relatively higher productivity than Escherichia coli HB101 and Bacteroides fragilis JCM11019T. Level of 7alpha-HSDH activity is higher in Bacteroides intestinalis AM-1 than in the other two strains Bacteroides fragilis NCTC 9343 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholan-24-oic acid + NADH
-
 ?
1.1.1.159 cholic acid + NAD+ in liquid culture, Bacteroides intestinalis AM-1 shows a relatively higher productivity than Escherichia coli HB101 and Bacteroides fragilis JCM11019T. Level of 7alpha-HSDH activity is higher in Bacteroides intestinalis AM-1 than in the other two strains Bacteroides intestinalis am-1 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholan-24-oic acid + NADH
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.159 7alpha-HSDH
-
 Bacteroides fragilis
1.1.1.159 7alpha-HSDH
-
 Bacteroides intestinalis
1.1.1.159 7alpha-HSDH
-
 Escherichia coli HB101