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Literature summary extracted from

  • O'Leary, K.A.; Day, A.J.; Needs, P.W.; Sly, W.S.; O'Brien, N.M.; Williamson, G.
    Flavonoid glucuronides are substrates for human liver beta-glucuronidase (2001), FEBS Lett., 503, 103-106.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.31 saccharo-1,4-lactone complete inhibition of liver enzyme Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.2.1.31 0.025
-
 kaempferol 3-O-beta-D-glucuronide pH 7.2, 37°C Homo sapiens
3.2.1.31 0.048
-
 quercetin 4'-O-beta-D-glucuronide pH 7.2, 37°C Homo sapiens
3.2.1.31 0.167
-
 quercetin-3-O-beta-D-glucuronide pH 7.2, 37°C Homo sapiens
3.2.1.31 0.237
-
 quercetin 7-O-beta-D-glucuronide pH 7.2, 37°C Homo sapiens
3.2.1.31 0.266
-
 equol 7-O-beta-D-glucuronide pH 7.2, 37°C Homo sapiens
3.2.1.31 0.272
-
 daidzein 7-O-beta-D-glucuronide pH 7.2, 37°C Homo sapiens
3.2.1.31 1.4
-
 4-nitrophenyl-beta-D-glucuronide pH 7.2, 37°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.31 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.31 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.31 4-nitrophenyl beta-D-glucuronide + H2O
-
 Homo sapiens 4-nitrophenol + D-glucuronic acid
-
 ?
3.2.1.31 daidzein 7-O-beta-D-glucuronide + H2O
-
 Homo sapiens daidzein + D-glucuronate
-
 ?
3.2.1.31 equol 7-O-beta-D-glucuronide + H2O
-
 Homo sapiens equol + D-glucuronate
-
 ?
3.2.1.31 kaempferol 3-O-beta-D-glucuronide + H2O
-
 Homo sapiens kaempferol + D-glucuronate
-
 ?
3.2.1.31 quercetin 3-O-beta-D-glucuronide + H2O
-
 Homo sapiens quercetin + D-glucuronate
-
 ?
3.2.1.31 quercetin 4'-O-beta-D-glucuronide + H2O
-
 Homo sapiens quercetin + beta-D-glucuronate
-
 ?
3.2.1.31 quercetin 7-O-beta-D-glucuronide + H2O
-
 Homo sapiens quercetin + D-glucuronate
-
 ?
3.2.1.31 quercetin-4'-O-glucuronide + H2O
-
 Homo sapiens quercetin + D-glucuronate
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.2.1.31 0.26
-
 quercetin 4'-O-beta-D-glucuronide pH 7.2, 37°C Homo sapiens
3.2.1.31 0.35
-
 equol 7-O-beta-D-glucuronide pH 7.2, 37°C Homo sapiens
3.2.1.31 0.65
-
 kaempferol 3-O-beta-D-glucuronide pH 7.2, 37°C Homo sapiens
3.2.1.31 0.67
-
 4-nitrophenyl-beta-D-glucuronide pH 7.2, 37°C Homo sapiens
3.2.1.31 1.07
-
 daidzein 7-O-beta-D-glucuronide pH 7.2, 37°C Homo sapiens
3.2.1.31 1.65
-
 quercetin 7-O-beta-D-glucuronide pH 7.2, 37°C Homo sapiens
3.2.1.31 1.9
-
 quercetin-3-O-beta-D-glucuronide pH 7.2, 37°C Homo sapiens