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Literature summary extracted from

  • Fournier, D.; Poirier, D.; Mazumdar, M.; Lin, S.X.
    Design and synthesis of bisubstrate inhibitors of type 1 17beta-hydroxysteroid dehydrogenase: overview and perspectives (2008), Eur. J. Med. Chem., 43, 2298-2306.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.62 (16alpa,17beta)-16-(3-bromopropyl)estra-1(10),2,4-triene-3,17-diol EM-251 Homo sapiens
1.1.1.62 (3-amino-5-[13-[(16beta,17beta)-3,17-dihydroxyestra-1(10),2,4-trien-16-yl]tridecyl]phenyl)acetic acid
-
 Homo sapiens
1.1.1.62 (3-[(4-aminophenyl)carbonyl]-5-[13-[(16beta,17beta)-3,17-dihydroxyestra-1(10),2,4-trien-16-yl]tridecyl]phenyl)acetic acid
-
 Homo sapiens
1.1.1.62 (3-[13-[(16beta,17beta)-3,17-dihydroxyestra-1(10),2,4-trien-16-yl]tridecyl]phenyl)acetic acid
-
 Homo sapiens
1.1.1.62 5'-O-[9-[(16beta,17beta)-3,17-dihydroxyestra-1(10),2,4-trien-16-yl]nonanoyl]adenosine EM-1745, bisubstrate inhibitor of 17beta-HSD1 Homo sapiens
1.1.1.62 EM-1745 bisubstrate inhibitor of 17beta-HSD1 Homo sapiens
1.1.1.62 N-butyl-6-[[(6beta,17beta)-3,17-dihydroxyestra-1(10),2,4-trien-6-yl]oxy]-N-methylhexanamide
-
 Homo sapiens
1.1.1.62 N-butyl-6-[[(6beta,17beta)-3,17-dihydroxyestra-1(10),2,4-trien-6-yl]sulfanyl]-N-methylhexanamide EM-678 Homo sapiens
1.1.1.62 N-butyl-7-[(6beta,17beta)-3,17-dihydroxyestra-1(10),2,4-trien-6-yl]-N-methylheptanamide
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.62 Homo sapiens P14061
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.62 dehydroepiandrosterone + NAD(P)H
-
 Homo sapiens androst-5-ene-3beta,17beta-diol + NAD(P)+
-
 ?
1.1.1.62 estradiol-17beta + NAD(P)+
-
 Homo sapiens estrone + NAD(P)H + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.62 17beta-HSD1
-
 Homo sapiens
1.1.1.62 type 1 17beta-hydroxysteroid dehydrogenase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.62 NAD(P)+
-
 Homo sapiens