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Literature summary extracted from

  • Nian, H.; Delage, B.; Ho, E.; Dashwood, R.H.
    Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds (2009), Environ. Mol. Mutagen., 50, 213-221.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.5.1.98 medicine HDAC inhibitors in food may help reverse aberrant patterns of histone changes in cancer cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.98 allyl mercaptan garlic organosulfur compounds can be metabolized to allyl mercaptan Homo sapiens
3.5.1.98 Butyrate
-
 Homo sapiens
3.5.1.98 Isothiocyanate found in cruciferous vegetables Homo sapiens
3.5.1.98 phenylbutyrate Buphenyl Homo sapiens
3.5.1.98 suberoylanilide hydroxamic acid SAHA Homo sapiens
3.5.1.98 sulforaphane SFN, found in broccoli sprouts Homo sapiens
3.5.1.98 trichostatin A TSA Homo sapiens
3.5.1.98 Valproic acid Depakene, Convulex Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.1.98 Zn2+
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.98 Homo sapiens Q9BY41
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.98 BPH-1 cell
-
 Homo sapiens
-
3.5.1.98 breast cancer cell line
-
 Homo sapiens
-
3.5.1.98 colonic cancer cell line
-
 Homo sapiens
-
3.5.1.98 HeLa cell
-
 Homo sapiens
-
3.5.1.98 LNCaP cell
-
 Homo sapiens
-
3.5.1.98 PC-3 cell
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
3.5.1.98 HDAC
-
 Homo sapiens
3.5.1.98 histone deacetylase
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.5.1.98 0.024
-
 allyl mercaptan human HDAC8 Homo sapiens
3.5.1.98 0.046
-
 Butyrate
-
 Homo sapiens