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Literature summary extracted from

  • Stojan, J.; Brunskole, M.; Rizner, T.
    Simultaneous binding of coenzyme and two ligand molecules into the active site of fungal trihydroxynaphthalene reductase (2009), Chem. Biol. Interact., 178, 268-273.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.252 expressed as a glutathione S-transferase (GST)-fusion protein in Escherichia coli BL21 cells Curvularia lunata

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.252 2,3-Dihydro-2,5-dihydroxy-4H-benzopyran-4-one activity of the holoenzyme is inhibited by high substrate concentrations. Apigenin prevents the substrate inhibition at high substrate concentrations Curvularia lunata
1.1.1.252 apigenin strong inhibition of 3HNR by apigenin at low 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one concentrations and a steep increase of the activity at higher 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one concentrations Curvularia lunata

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.252 Curvularia lunata
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.252 by affinity binding followed by cleavage with thrombin Curvularia lunata

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.252 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one + NADP+
-
 Curvularia lunata 4,5-dihydroxy-2H-benzopyran-2-one + NADPH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.252 3HNR
-
 Curvularia lunata
1.1.1.252 trihydroxynaphthalene reductase
-
 Curvularia lunata

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.252 NADP+
-
 Curvularia lunata