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Literature summary extracted from
- Doxorubicin and paclitaxel-loaded lipid-based nanoparticles overcome multidrug resistance by inhibiting P-glycoprotein and depleting ATP (2009), Cancer Res., 69, 3918-3926.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 7.6.2.2 | P-glycoprotein overexpressionin NCI/ADR-RES and OVCAR-8 ovarian carcinoma cells | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.6.2.2 | nanoparticles | doxorubicin and paclitaxel nanoparticles inhibit P-glycoprotein and transiently deplete ATP, while cyclosporine A and polystyrene nanoparticles do not, overview | Homo sapiens |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 7.6.2.2 | membrane | - |
Homo sapiens | 16020 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.6.2.2 | Mg2+ | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.6.2.2 | ATP + H2O + doxorubicin/in | Homo sapiens | - |
ADP + phosphate + doxorubicin/out | - |
? | |
| 7.6.2.2 | ATP + H2O + paclitaxel/in | Homo sapiens | - |
ADP + phosphate + paclitaxel/out | - |
? | |
| 7.6.2.2 | ATP + H2O + xenobiotic/in | Homo sapiens | the P-glycoprotein mediates multidrug resistance, which can be overcome by enzyme inhibition and ATP depletion allowing drug containing nanoparticles to target both drug and biological mechanisms | ADP + phosphate + xenobiotic/out | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.6.2.2 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 7.6.2.2 | NCI/ADR-RES cell | - |
Homo sapiens | - |
| 7.6.2.2 | ovary carcinoma cell | - |
Homo sapiens | - |
| 7.6.2.2 | OVCAR-8 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.6.2.2 | ATP + H2O + calcein acetoxymethylester/in | - |
Homo sapiens | ADP + phosphate + calcein acetoxymethylester/out | - |
? | |
| 7.6.2.2 | ATP + H2O + doxorubicin/in | - |
Homo sapiens | ADP + phosphate + doxorubicin/out | - |
? | |
| 7.6.2.2 | ATP + H2O + paclitaxel/in | - |
Homo sapiens | ADP + phosphate + paclitaxel/out | - |
? | |
| 7.6.2.2 | ATP + H2O + xenobiotic/in | - |
Homo sapiens | ADP + phosphate + xenobiotic/out | - |
? | |
| 7.6.2.2 | ATP + H2O + xenobiotic/in | the P-glycoprotein mediates multidrug resistance, which can be overcome by enzyme inhibition and ATP depletion allowing drug containing nanoparticles to target both drug and biological mechanisms | Homo sapiens | ADP + phosphate + xenobiotic/out | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 7.6.2.2 | P-glycoprotein | - |
Homo sapiens |
| 7.6.2.2 | P-gp | - |
Homo sapiens |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 7.6.2.2 | 37 | - |
assay at | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 7.6.2.2 | 7.4 | - |
assay at | Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.6.2.2 | ATP | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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