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Literature summary extracted from

  • Bae, Y.; Cai, G.; Kim, S.; Zo, Y.; Kong, Y.
    Modular evolution of glutathione peroxidase genes in association with different biochemical properties of their encoded proteins in invertebrate animals (2009), BMC Evol. Biol., 9, 72.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.11.1.12 additional information comparative analysis of invertebrate GPx genes provides information evidence to support the modular pathways of GPx evolution, which have been accompanied with sporadic expansion-deletion and exon-intron remodeling, the study would be beneficial to get detailed insights into the complex GPx evolution, and to understand the molecular basis of the specialized physiological implications of the antioxidant system in their respective organisms animal

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.11.1.12 glutathione + a lipid hydroperoxide animal
-
 glutathione disulfide + lipid + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.11.1.9 Brugia pahangi P67878
-
-
1.11.1.9 Homo sapiens P07203
-
-
1.11.1.9 Homo sapiens P22352
-
-
1.11.1.9 Paragonimus westermani Q1PBM0
-
-
1.11.1.9 Paragonimus westermani Q1PBM1
-
-
1.11.1.9 Schistosoma japonicum Q86EQ5
-
-
1.11.1.9 Schistosoma mansoni Q00277
-
-
1.11.1.12 animal
-
 invertebrate animals, the GPx genes are isolated from various platyhelminths via in silico screening
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.11.1.9 Superdex 75 gel filtration and DEAE column chromatography Schistosoma mansoni
1.11.1.9 Superdex 75 gel filtration and DEAE column chromatography Paragonimus westermani
1.11.1.9 Superdex 75 gel filtration and DEAE column chromatography Brugia pahangi
1.11.1.9 Superdex 75 gel filtration and DEAE column chromatography Schistosoma japonicum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.1.9 H2O2 + GSH
-
 Homo sapiens H2O + GSSG
-
 ?
1.11.1.9 H2O2 + GSH
-
 Schistosoma mansoni H2O + GSSG
-
 ?
1.11.1.9 H2O2 + GSH
-
 Paragonimus westermani H2O + GSSG
-
 ?
1.11.1.9 H2O2 + GSH
-
 Brugia pahangi H2O + GSSG
-
 ?
1.11.1.9 H2O2 + GSH
-
 Schistosoma japonicum H2O + GSSG
-
 ?
1.11.1.12 glutathione + a lipid hydroperoxide
-
 animal glutathione disulfide + lipid + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.11.1.9 GPX1
-
 Homo sapiens
1.11.1.9 GPX1
-
 Paragonimus westermani
1.11.1.9 Gpx2
-
 Paragonimus westermani
1.11.1.9 GPX3
-
 Homo sapiens
1.11.1.12 PHGPX
-
 animal
1.11.1.12 phospholipid hydroperoxide glutathione peroxidase
-
 animal

Cofactor

EC Number Cofactor Comment Organism Structure
1.11.1.12 glutathione
-
 animal