EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
4.1.1.90 | additional information | analysis of a Ggcx+/- intercross reveals a partial developmental block with only 50% of expected Ggcx-/- offspring surviving to term, with the latter animals dying uniformly at birth of massive intra-abdominal hemorrhage. This phenotype closely resembles the partial midembryonic loss and postnatal hemorrhage previously reported for both prothrombin and factor V (F5)deficient mice. Ggcx-/-, dying uniformly at birth of massive intra-abdominal hemorrhage. Heterozygous mice carrying a null mutation at the gamma-carboxylase (Ggcx) gene exhibit normal development and survival with no evidence of hemorrhage and normal functional activity of the vitamin Kdependent clotting factors IX, X, and prothrombin | Mus musculus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
4.1.1.90 | endoplasmic reticulum | transmembrane protein | Mus musculus | 5783 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.1.1.90 | additional information | Mus musculus | an essential posttranslational modification required for the biological activity of a number of proteins, including proteins involved in blood coagulation and its regulation | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.1.1.90 | Mus musculus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
4.1.1.90 | blood plasma | coagulation assays | Mus musculus | - |
4.1.1.90 | CJ7 cell | gamma-carboxylase gene targeting | Mus musculus | - |
4.1.1.90 | liver | preparation of solubilized gamma-carboxylase | Mus musculus | - |
4.1.1.90 | R1 cell | gamma-carboxylase gene targeting | Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.1.1.90 | FLEEL + CO2 + O2 + vitamin K1 hydroquinone | a synthetic peptide substrate, assay for vitamin Kdependent carboxylase activity | Mus musculus | ? + vitamin K1 epoxide + H2O | - |
? | |
4.1.1.90 | L-glutamate + CO2 + O2 + vitamin K hydroquinone | - |
Mus musculus | gamma-carboxy L-glutamate + vitamin K epoxide + H2O | - |
? | |
4.1.1.90 | additional information | an essential posttranslational modification required for the biological activity of a number of proteins, including proteins involved in blood coagulation and its regulation | Mus musculus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.1.1.90 | gamma-carboxylase | - |
Mus musculus |
4.1.1.90 | gamma-glutamyl carboxylase | - |
Mus musculus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
4.1.1.90 | vitamin K1 | - |
Mus musculus |