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Literature summary extracted from

  • Chapuis, J.C.; Khdour, O.; Cai, X.; Lu, J.; Hecht, S.M.
    Synthesis and characterization of Deltalac-acetogenins that potently inhibit mitochondrial complex I (2009), Bioorg. Med. Chem., 17, 2204-2209.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.3.1 (1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyundec-3-yn-1-yl]octahydro-2,2'-bifuran-5-yl]dodec-4-yn-1-ol
-
 Bos taurus
1.6.3.1 (1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyundecyl]octahydro-2,2'-bifuran-5-yl]dodecan-1-ol
-
 Bos taurus
1.6.3.1 (1R,1'R)-1,1'-((2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diyl)-bis-(6-(4-n-butylphenoxy)hex-3-yn-1-ol)
-
 Bos taurus
1.6.3.1 (1R,1'R)-1,1'-((2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diyl)-bis-(6-(4-n-butylphenoxy)hexan-1-ol)
-
 Bos taurus
7.1.1.2 (1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyundec-3-yn-1-yl]octahydro-2,2'-bifuran-5-yl]dodec-4-yn-1-ol
-
 Bos taurus
7.1.1.2 (1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyundecyl]octahydro-2,2'-bifuran-5-yl]dodecan-1-ol
-
 Bos taurus
7.1.1.2 (1R,1'R)-1,1'-((2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diyl)-bis-(6-(4-n-butylphenoxy)hex-3-yn-1-ol)
-
 Bos taurus
7.1.1.2 (1R,1'R)-1,1'-((2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diyl)-bis-(6-(4-n-butylphenoxy)hexan-1-ol)
-
 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.6.3.1 mitochondrion
-
 Bos taurus 5739
-
7.1.1.2 mitochondrion
-
 Bos taurus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.6.3.1 Bos taurus
-
-
-
7.1.1.2 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.3.1 heart
-
 Bos taurus
-
7.1.1.2 heart
-
 Bos taurus
-

Synonyms

EC Number Synonyms Comment Organism
1.6.3.1 NADH oxidase
-
 Bos taurus
7.1.1.2 complex I
-
 Bos taurus
7.1.1.2 NADH-Q1 oxidoreductase
-
 Bos taurus
7.1.1.2 NADH:ubiquinone oxidoreductase
-
 Bos taurus
7.1.1.2 NADH–ubiquinone Q1 oxidoreductase
-
 Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.6.3.1 30
-
 assay at Bos taurus
7.1.1.2 30
-
 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.6.3.1 7.4
-
 assay at Bos taurus
7.1.1.2 7.4
-
 assay at Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.6.3.1 0.0000123
-
 (1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyundecyl]octahydro-2,2'-bifuran-5-yl]dodecan-1-ol
-
 Bos taurus
1.6.3.1 0.0000196
-
 (1R,1'R)-1,1'-((2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diyl)-bis-(6-(4-n-butylphenoxy)hexan-1-ol)
-
 Bos taurus
1.6.3.1 0.0000301
-
 (1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyundec-3-yn-1-yl]octahydro-2,2'-bifuran-5-yl]dodec-4-yn-1-ol
-
 Bos taurus
1.6.3.1 0.0000388
-
 (1R,1'R)-1,1'-((2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diyl)-bis-(6-(4-n-butylphenoxy)hex-3-yn-1-ol)
-
 Bos taurus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
7.1.1.2 additional information
-
 IC50: above 15 mM Bos taurus (1R,1'R)-1,1'-((2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diyl)-bis-(6-(4-n-butylphenoxy)hexan-1-ol)
7.1.1.2 0.000048
-
-
 Bos taurus (1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyundec-3-yn-1-yl]octahydro-2,2'-bifuran-5-yl]dodec-4-yn-1-ol
7.1.1.2 0.0017
-
-
 Bos taurus (1R,1'R)-1,1'-((2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diyl)-bis-(6-(4-n-butylphenoxy)hex-3-yn-1-ol)
7.1.1.2 0.0104
-
-
 Bos taurus (1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyundecyl]octahydro-2,2'-bifuran-5-yl]dodecan-1-ol