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Literature summary extracted from

  • Isik, S.; Kockar, F.; Aydin, M.; Arslan, O.; Guler, O.O.; Innocenti, A.; Scozzafava, A.; Supuran, C.T.
    Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates (2009), Bioorg. Med. Chem., 17, 1158-1163.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.1 expressed in Escherichia coli BL21 (DE3) cells Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.1 1-[(aminooxy)sulfinyl]-4-methylbenzene
-
 Saccharomyces cerevisiae
4.2.1.1 1-[4-[(aminooxy)sulfinyl]phenyl]methanamine
-
 Saccharomyces cerevisiae
4.2.1.1 2,4-bis[(aminooxy)sulfinyl]-5-(trifluoromethyl)aniline
-
 Saccharomyces cerevisiae
4.2.1.1 2,4-bis[(aminooxy)sulfinyl]-5-chloroaniline
-
 Saccharomyces cerevisiae
4.2.1.1 2-[(aminooxy)sulfinyl]-5-(2-chlorophenyl)-1,3,4-thiadiazole
-
 Saccharomyces cerevisiae
4.2.1.1 2-[(aminooxy)sulfinyl]aniline
-
 Saccharomyces cerevisiae
4.2.1.1 2-[4-[(aminooxy)sulfinyl]phenyl]ethanamine
-
 Saccharomyces cerevisiae
4.2.1.1 2-[4-[(aminooxy)sulfinyl]phenyl]ethanol
-
 Saccharomyces cerevisiae
4.2.1.1 3-[4-[(aminooxy)sulfinyl]phenyl]propanoic acid
-
 Saccharomyces cerevisiae
4.2.1.1 4,5-dichloro-benzene-1,3-disulfonamide shows effective carbonic anhydrase inhibitory activity Saccharomyces cerevisiae
4.2.1.1 4-(2-amino-pyrimidin-4-yl)-benzenesulfonamide best inhibitor Saccharomyces cerevisiae
4.2.1.1 4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
-
 Saccharomyces cerevisiae
4.2.1.1 4-amino-N-[4-[(aminooxy)sulfinyl]benzyl]benzenesulfonamide
-
 Saccharomyces cerevisiae
4.2.1.1 4-[(aminooxy)sulfinyl]-2-bromoaniline
-
 Saccharomyces cerevisiae
4.2.1.1 4-[(aminooxy)sulfinyl]-2-chloroaniline
-
 Saccharomyces cerevisiae
4.2.1.1 4-[(aminooxy)sulfinyl]-2-fluoroaniline
-
 Saccharomyces cerevisiae
4.2.1.1 4-[(aminooxy)sulfinyl]-2-iodoaniline
-
 Saccharomyces cerevisiae
4.2.1.1 4-[(aminooxy)sulfinyl]aniline
-
 Saccharomyces cerevisiae
4.2.1.1 4-[(aminooxy)sulfinyl]benzoic acid
-
 Saccharomyces cerevisiae
4.2.1.1 5-[(aminooxy)sulfinyl]-1,3,4-thiadiazol-2-amine
-
 Saccharomyces cerevisiae
4.2.1.1 5-[(aminooxy)sulfinyl]-3-methyl-1,3,4-thiadiazol-2(3H)-imine
-
 Saccharomyces cerevisiae
4.2.1.1 5-[[(4-aminophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
-
 Saccharomyces cerevisiae
4.2.1.1 acetazolamide shows effective carbonic anhydrase inhibitory activity Saccharomyces cerevisiae
4.2.1.1 benzolamide shows effective carbonic anhydrase inhibitory activity Saccharomyces cerevisiae
4.2.1.1 brinzolamide shows effective carbonic anhydrase inhibitory activity Saccharomyces cerevisiae
4.2.1.1 celecoxib shows effective carbonic anhydrase inhibitory activity Saccharomyces cerevisiae
4.2.1.1 dorzolamide shows effective carbonic anhydrase inhibitory activity Saccharomyces cerevisiae
4.2.1.1 ethoxzolamide shows effective carbonic anhydrase inhibitory activity Saccharomyces cerevisiae
4.2.1.1 indisulam shows effective carbonic anhydrase inhibitory activity Saccharomyces cerevisiae
4.2.1.1 methazolamide shows effective carbonic anhydrase inhibitory activity Saccharomyces cerevisiae
4.2.1.1 saccharin shows effective carbonic anhydrase inhibitory activity Saccharomyces cerevisiae
4.2.1.1 sulpiride shows effective carbonic anhydrase inhibitory activity Saccharomyces cerevisiae
4.2.1.1 sulthiame shows effective carbonic anhydrase inhibitory activity Saccharomyces cerevisiae
4.2.1.1 topiramate shows effective carbonic anhydrase inhibitory activity Saccharomyces cerevisiae
4.2.1.1 valdecoxib shows effective carbonic anhydrase inhibitory activity Saccharomyces cerevisiae
4.2.1.1 zonisamide shows effective carbonic anhydrase inhibitory activity Saccharomyces cerevisiae
4.2.1.1 [4-[(aminooxy)sulfinyl]phenyl]methanol
-
 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.1 CO2 + H2O Saccharomyces cerevisiae
-
 H2CO3
-
 r

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.1 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.2.1.1 ammonium sulfate precipitation and Sephadex G-100 gel filtration Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.1 CO2 + H2O
-
 Saccharomyces cerevisiae H2CO3
-
 r

Synonyms

EC Number Synonyms Comment Organism
4.2.1.1 beta-CA
-
 Saccharomyces cerevisiae
4.2.1.1 beta-carbonic anhydrase
-
 Saccharomyces cerevisiae
4.2.1.1 carbonic anhydrase
-
 Saccharomyces cerevisiae

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.2.1.1 940000
-
 CO2
-
 Saccharomyces cerevisiae

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.2.1.1 0.0000151
-
 4-(2-amino-pyrimidin-4-yl)-benzenesulfonamide
-
 Saccharomyces cerevisiae
4.2.1.1 0.0000826
-
 acetazolamide
-
 Saccharomyces cerevisiae
4.2.1.1 0.0000984
-
 ethoxzolamide
-
 Saccharomyces cerevisiae
4.2.1.1 0.000103
-
 4,5-dichloro-benzene-1,3-disulfonamide
-
 Saccharomyces cerevisiae
4.2.1.1 0.000106
-
 zonisamide
-
 Saccharomyces cerevisiae
4.2.1.1 0.000108
-
 celecoxib
-
 Saccharomyces cerevisiae
4.2.1.1 0.00011
-
 topiramate
-
 Saccharomyces cerevisiae
4.2.1.1 0.00011
-
 dorzolamide
-
 Saccharomyces cerevisiae
4.2.1.1 0.000111
-
 benzolamide
-
 Saccharomyces cerevisiae
4.2.1.1 0.000114
-
 brinzolamide
-
 Saccharomyces cerevisiae
4.2.1.1 0.000119
-
 methazolamide
-
 Saccharomyces cerevisiae
4.2.1.1 0.000124
-
 sulpiride
-
 Saccharomyces cerevisiae
4.2.1.1 0.000133
-
 indisulam
-
 Saccharomyces cerevisiae
4.2.1.1 0.000654
-
 valdecoxib
-
 Saccharomyces cerevisiae
4.2.1.1 0.00102
-
 sulthiame
-
 Saccharomyces cerevisiae
4.2.1.1 12.5
-
 saccharin
-
 Saccharomyces cerevisiae

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
4.2.1.1 0.0000151
-
-
 Saccharomyces cerevisiae 2-[(aminooxy)sulfinyl]-5-(2-chlorophenyl)-1,3,4-thiadiazole
4.2.1.1 0.000124
-
-
 Saccharomyces cerevisiae 4-amino-N-[5-[(aminooxy)sulfinyl]-1,3,4-thiadiazol-2-yl]benzenesulfonamide
4.2.1.1 0.000154
-
-
 Saccharomyces cerevisiae 4-amino-N-(2-[4-[(aminooxy)sulfinyl]phenyl]ethyl)benzenesulfonamide
4.2.1.1 0.000163
-
-
 Saccharomyces cerevisiae 2-[4-[(aminooxy)sulfinyl]phenyl]ethanamine
4.2.1.1 0.000165
-
-
 Saccharomyces cerevisiae 3-[4-[(aminooxy)sulfinyl]phenyl]propanoic acid
4.2.1.1 0.000166
-
-
 Saccharomyces cerevisiae 4-amino-N-[4-[(aminooxy)sulfinyl]benzyl]benzenesulfonamide
4.2.1.1 0.000169
-
-
 Saccharomyces cerevisiae 2,4-bis[(aminooxy)sulfinyl]-5-chloroaniline
4.2.1.1 0.000223
-
-
 Saccharomyces cerevisiae 2,4-bis[(aminooxy)sulfinyl]-5-(trifluoromethyl)aniline
4.2.1.1 0.000248
-
-
 Saccharomyces cerevisiae 4-[(aminooxy)sulfinyl]-2-bromoaniline
4.2.1.1 0.00036
-
-
 Saccharomyces cerevisiae 5-[(aminooxy)sulfinyl]-3-methyl-1,3,4-thiadiazol-2(3H)-imine
4.2.1.1 0.000389
-
-
 Saccharomyces cerevisiae 4-[(aminooxy)sulfinyl]-2-fluoroaniline
4.2.1.1 0.000433
-
-
 Saccharomyces cerevisiae 1-[4-[(aminooxy)sulfinyl]phenyl]methanamine
4.2.1.1 0.000447
-
-
 Saccharomyces cerevisiae 5-[(aminooxy)sulfinyl]-1,3,4-thiadiazol-2-amine
4.2.1.1 0.000457
-
-
 Saccharomyces cerevisiae 4-[(aminooxy)sulfinyl]-2-chloroaniline
4.2.1.1 0.000565
-
-
 Saccharomyces cerevisiae [4-[(aminooxy)sulfinyl]phenyl]methanol
4.2.1.1 0.000976
-
-
 Saccharomyces cerevisiae 4-[(aminooxy)sulfinyl]-2-iodoaniline
4.2.1.1 0.00754
-
-
 Saccharomyces cerevisiae 4-[(aminooxy)sulfinyl]benzoic acid
4.2.1.1 0.00897
-
-
 Saccharomyces cerevisiae 2-[4-[(aminooxy)sulfinyl]phenyl]ethanol
4.2.1.1 0.0123
-
-
 Saccharomyces cerevisiae 2-[(aminooxy)sulfinyl]aniline
4.2.1.1 0.0161
-
-
 Saccharomyces cerevisiae 1-[(aminooxy)sulfinyl]-4-methylbenzene
4.2.1.1 0.0185
-
-
 Saccharomyces cerevisiae 4-[(aminooxy)sulfinyl]aniline