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Literature summary extracted from

  • Uto, Y.; Ogata, T.; Harada, J.; Kiyotsuka, Y.; Ueno, Y.; Miyazawa, Y.; Kurata, H.; Deguchi, T.; Watanabe, N.; Takagi, T.; Wakimoto, S.; Okuyama, R.; Abe, M.; Kurikawa, N.; Kawamura, S.; Yamato, M.; Osumi, J.
    Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part I: Discovery of 3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide (2009), Bioorg. Med. Chem. Lett., 19, 4151-4158.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.19.1 (2E)-3-(4-methoxyphenyl)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]prop-2-enamide
-
 Homo sapiens
1.14.19.1 (2E)-3-(4-methoxyphenyl)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]prop-2-enamide
-
 Mus musculus
1.14.19.1 3,4-dimethoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
 Homo sapiens
1.14.19.1 3,4-dimethoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
 Mus musculus
1.14.19.1 3,4-dimethyl-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
 Homo sapiens
1.14.19.1 3,4-dimethyl-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
 Mus musculus
1.14.19.1 3-(2,2-dihydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
 Homo sapiens
1.14.19.1 3-(2,2-dihydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
 Mus musculus
1.14.19.1 3-(2,3-dihydroxypropoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
 Homo sapiens
1.14.19.1 3-(2,3-dihydroxypropoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
 Mus musculus
1.14.19.1 3-(2-hydroxy-2-methylpropoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
 Homo sapiens
1.14.19.1 3-(2-hydroxy-2-methylpropoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
 Mus musculus
1.14.19.1 3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide highly potent and orally bioavailable thiazole-based SCD-1 inhibitor Homo sapiens
1.14.19.1 3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide highly potent and orally bioavailable thiazole-based SCD-1 inhibitor Mus musculus
1.14.19.1 3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethoxy)benzyl]-1,3-thiazol-2-yl]benzamide
-
 Homo sapiens
1.14.19.1 3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethoxy)benzyl]-1,3-thiazol-2-yl]benzamide
-
 Mus musculus
1.14.19.1 3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
 Homo sapiens
1.14.19.1 3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
 Mus musculus
1.14.19.1 3-(3-hydroxypropoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
 Homo sapiens
1.14.19.1 3-(3-hydroxypropoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
 Mus musculus
1.14.19.1 3-methoxy-4-(2-morpholin-4-ylethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
 Homo sapiens
1.14.19.1 3-methoxy-4-(2-morpholin-4-ylethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
 Mus musculus
1.14.19.1 3-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
 Homo sapiens
1.14.19.1 3-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
 Mus musculus
1.14.19.1 4-(2-hydroxyethoxy)-3-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
 Homo sapiens
1.14.19.1 4-(2-hydroxyethoxy)-3-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
 Mus musculus
1.14.19.1 4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
 Homo sapiens
1.14.19.1 4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
 Mus musculus
1.14.19.1 6-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]naphthalene-2-carboxamide
-
 Homo sapiens
1.14.19.1 6-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]naphthalene-2-carboxamide
-
 Mus musculus
1.14.19.1 N-[5-(2,5-dichlorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
 Homo sapiens
1.14.19.1 N-[5-(2,5-dichlorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
 Mus musculus
1.14.19.1 N-[5-(3,4-dichlorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
 Homo sapiens
1.14.19.1 N-[5-(3,4-dichlorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
 Mus musculus
1.14.19.1 N-[5-(3,4-difluorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
 Homo sapiens
1.14.19.1 N-[5-(3,4-difluorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
 Mus musculus
1.14.19.1 N-[5-(3,5-dichlorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
 Homo sapiens
1.14.19.1 N-[5-(3,5-dichlorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
 Mus musculus
1.14.19.1 N-[5-(3,5-difluorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
 Homo sapiens
1.14.19.1 N-[5-(3,5-difluorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
 Mus musculus
1.14.19.1 N-[5-(3-chloro-4-fluorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
 Homo sapiens
1.14.19.1 N-[5-(3-chloro-4-fluorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
 Mus musculus
1.14.19.1 N-[5-(3-chlorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
 Homo sapiens
1.14.19.1 N-[5-(3-chlorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
 Mus musculus
1.14.19.1 N-[5-(3-fluoro-4-methylbenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
 Homo sapiens
1.14.19.1 N-[5-(3-fluoro-4-methylbenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
 Mus musculus
1.14.19.1 N-[5-(3-fluorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
 Homo sapiens
1.14.19.1 N-[5-(3-fluorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
 Mus musculus
1.14.19.1 N-[5-(3-tert-butylbenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
 Homo sapiens
1.14.19.1 N-[5-(3-tert-butylbenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
 Mus musculus
1.14.19.1 N-[5-[3,5-bis(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
 Homo sapiens
1.14.19.1 N-[5-[3,5-bis(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
 Mus musculus
1.14.19.1 N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]naphthalene-2-carboxamide
-
 Mus musculus
1.14.19.1 N-[5-[4-fluoro-3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
 Homo sapiens
1.14.19.1 N-[5-[4-fluoro-3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
 Mus musculus
1.14.19.1 N-{5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl}naphthalene-2-carboxamide
-
 Homo sapiens
1.14.19.1 [2-methoxy-4-([5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]carbamoyl)phenoxy]acetic acid
-
 Homo sapiens
1.14.19.1 [2-methoxy-4-([5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]carbamoyl)phenoxy]acetic acid
-
 Mus musculus
1.14.19.1 [2-methoxy-5-([5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]carbamoyl)phenoxy]acetic acid
-
 Homo sapiens
1.14.19.1 [2-methoxy-5-([5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]carbamoyl)phenoxy]acetic acid
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.19.1 microsome
-
 Mus musculus
-
-
1.14.19.1 microsome
-
 Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.1 Homo sapiens
-
-
-
1.14.19.1 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.1 liver
-
 Mus musculus
-
1.14.19.1 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.1 stearoyl-CoA + NADH + H+ + O2
-
 Mus musculus oleoyl-CoA + NAD+ + H2O
-
 ?
1.14.19.1 stearoyl-CoA + NADH + H+ + O2
-
 Homo sapiens oleoyl-CoA + NAD+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.1 SCD-1
-
 Mus musculus
1.14.19.1 SCD-1
-
 Homo sapiens
1.14.19.1 stearoyl-CoA desaturase-1
-
 Mus musculus
1.14.19.1 stearoyl-CoA desaturase-1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.1 NADH
-
 Mus musculus
1.14.19.1 NADH
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.19.1 0.0000001
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Mus musculus N-[5-(3,5-difluorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
1.14.19.1 0.0000002
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Mus musculus N-[5-[4-fluoro-3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
1.14.19.1 0.0000006
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Mus musculus N-[5-[3,5-bis(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
1.14.19.1 0.0000007
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Mus musculus N-[5-(3,5-dichlorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
1.14.19.1 0.0000008
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Mus musculus N-[5-(3,4-dichlorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
1.14.19.1 0.000001
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Mus musculus N-[5-(3-chlorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
1.14.19.1 0.000001
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Mus musculus N-[5-(3-chloro-4-fluorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
1.14.19.1 0.000002
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Mus musculus 3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
1.14.19.1 0.000002
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Mus musculus (2E)-3-(4-methoxyphenyl)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]prop-2-enamide
1.14.19.1 0.000002
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Mus musculus N-[5-(3-fluorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
1.14.19.1 0.000002
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Mus musculus N-[5-(3,4-difluorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
1.14.19.1 0.000002
-
 in 250 mM sucrose, 150 mM KCl, 40 mM NaF, 5 mM MgCl2, 100 mM sodium phosphate, pH 7.4, at 37°C Mus musculus 3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide
1.14.19.1 0.000003
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens (2E)-3-(4-methoxyphenyl)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]prop-2-enamide
1.14.19.1 0.000003
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Mus musculus 4-(2-hydroxyethoxy)-3-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
1.14.19.1 0.000003
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Mus musculus 3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethoxy)benzyl]-1,3-thiazol-2-yl]benzamide
1.14.19.1 0.000003
-
 in 250 mM sucrose, 150 mM KCl, 40 mM NaF, 5 mM MgCl2, 100 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens 3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide
1.14.19.1 0.000005
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Mus musculus 6-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]naphthalene-2-carboxamide
1.14.19.1 0.000008
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens N-[5-[4-fluoro-3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
1.14.19.1 0.000009
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens 6-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]naphthalene-2-carboxamide
1.14.19.1 0.000009
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens N-[5-(3-chlorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
1.14.19.1 0.000009
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Mus musculus N-[5-(2,5-dichlorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
1.14.19.1 0.00001
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens 4-(2-hydroxyethoxy)-3-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
1.14.19.1 0.000013
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens N-[5-(3,5-dichlorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
1.14.19.1 0.000013
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens N-[5-(3,4-dichlorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
1.14.19.1 0.000015
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens 3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
1.14.19.1 0.000017
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens N-[5-(3-chloro-4-fluorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
1.14.19.1 0.000022
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Mus musculus N-[5-(3-fluoro-4-methylbenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
1.14.19.1 0.000026
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens N-[5-[3,5-bis(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
1.14.19.1 0.000034
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens N-[5-(3-fluorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
1.14.19.1 0.000034
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens N-[5-(3,4-difluorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
1.14.19.1 0.000059
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens 3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethoxy)benzyl]-1,3-thiazol-2-yl]benzamide
1.14.19.1 0.000076
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Mus musculus 3,4-dimethoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
1.14.19.1 0.000116
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens N-[5-(3,5-difluorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
1.14.19.1 0.000145
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens 3,4-dimethoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
1.14.19.1 0.000193
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Mus musculus 3-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
1.14.19.1 0.000429
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens N-[5-(2,5-dichlorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
1.14.19.1 0.000528
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Mus musculus 3-methoxy-4-(2-morpholin-4-ylethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
1.14.19.1 0.000639
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens N-[5-(3-fluoro-4-methylbenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
1.14.19.1 0.000915
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens 3-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
1.14.19.1 0.001218
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens 4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
1.14.19.1 0.001307
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Mus musculus N-[5-(3-tert-butylbenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
1.14.19.1 0.001402
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens 3-methoxy-4-(2-morpholin-4-ylethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
1.14.19.1 0.002162
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens 3-(2,2-dihydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
1.14.19.1 0.00217
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Mus musculus 3-(2,2-dihydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
1.14.19.1 0.004377
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens [2-methoxy-4-([5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]carbamoyl)phenoxy]acetic acid
1.14.19.1 0.008218
-
 in 100 mM sodium phosphate, pH 7.4, at 37°C Mus musculus 3,4-dimethyl-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
1.14.19.1 0.009999
-
 IC50 above 0.009999 mM, in 100 mM sodium phosphate, pH 7.4, at 37°C Mus musculus [2-methoxy-5-([5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]carbamoyl)phenoxy]acetic acid
1.14.19.1 0.009999
-
 IC50 above 0.009999 mM, in 100 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens 3-(3-hydroxypropoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
1.14.19.1 0.009999
-
 IC50 above 0.009999 mM, in 100 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens 3-(2,3-dihydroxypropoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
1.14.19.1 0.009999
-
 IC50 above 0.009999 mM, in 100 mM sodium phosphate, pH 7.4, at 37°C Mus musculus 3-(2-hydroxy-2-methylpropoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
1.14.19.1 0.01
-
 IC50 above 0.01 mM, in 100 mM sodium phosphate, pH 7.4, at 37°C Mus musculus N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]naphthalene-2-carboxamide