Literature summary extracted from

Innocenti, A.; Zimmerman, S.A.; Scozzafava, A.; Ferry, J.G.; Supuran, C.T.
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines (2008), Bioorg. Med. Chem. Lett., 18, 6194-6198.

Activating Compound

EC Number	Activating Compound	Comment	Organism
4.2.1.1	1-(2-aminoethyl)-piperazine	-	Methanothermobacter thermautotrophicus
4.2.1.1	1-(2-aminoethyl)-piperazine	effectively activates Zn-gamma-class carbonic anhydrase	Methanosarcina thermophila
4.2.1.1	2-pyridyl-methylamine	-	Methanothermobacter thermautotrophicus
4.2.1.1	2-pyridyl-methylamine	-	Methanosarcina thermophila
4.2.1.1	2-pyridylmethylamine	-	Methanothermobacter thermautotrophicus
4.2.1.1	2-pyridylmethylamine	effectively activates Zn-gamma-class carbonic anhydrase	Methanosarcina thermophila
4.2.1.1	4-(2-aminoethyl)-morpholine	-	Methanothermobacter thermautotrophicus
4.2.1.1	4-(2-aminoethyl)-morpholine	-	Methanosarcina thermophila
4.2.1.1	4-amino-L-phenylalanine	-	Methanothermobacter thermautotrophicus
4.2.1.1	4-amino-L-phenylalanine	-	Methanosarcina thermophila
4.2.1.1	D-3,4-dihydroxyphenylalanine	-	Methanothermobacter thermautotrophicus
4.2.1.1	D-3,4-dihydroxyphenylalanine	-	Methanosarcina thermophila
4.2.1.1	D-His	-	Methanothermobacter thermautotrophicus
4.2.1.1	D-His	-	Methanosarcina thermophila
4.2.1.1	D-Phe	-	Methanosarcina thermophila
4.2.1.1	D-Phe	effective beta-class carbonic anhydrase activator	Methanothermobacter thermautotrophicus
4.2.1.1	D-Trp	-	Methanothermobacter thermautotrophicus
4.2.1.1	D-Trp	-	Methanosarcina thermophila
4.2.1.1	dopamine	-	Methanothermobacter thermautotrophicus
4.2.1.1	dopamine	-	Methanosarcina thermophila
4.2.1.1	histamine	-	Methanothermobacter thermautotrophicus
4.2.1.1	histamine	-	Methanosarcina thermophila
4.2.1.1	L-3,4-dihydroxyphenylalanine	-	Methanothermobacter thermautotrophicus
4.2.1.1	L-3,4-dihydroxyphenylalanine	-	Methanosarcina thermophila
4.2.1.1	L-adrenaline	-	Methanothermobacter thermautotrophicus
4.2.1.1	L-adrenaline	-	Methanosarcina thermophila
4.2.1.1	L-His	-	Methanothermobacter thermautotrophicus
4.2.1.1	L-His	-	Methanosarcina thermophila
4.2.1.1	L-Phe	-	Methanothermobacter thermautotrophicus
4.2.1.1	L-Phe	-	Methanosarcina thermophila
4.2.1.1	L-Trp	-	Methanothermobacter thermautotrophicus
4.2.1.1	L-Trp	-	Methanosarcina thermophila
4.2.1.1	L-Tyr	-	Methanosarcina thermophila
4.2.1.1	L-Tyr	effective beta-class carbonic anhydrase activator	Methanothermobacter thermautotrophicus
4.2.1.1	serotonin	-	Methanothermobacter thermautotrophicus
4.2.1.1	serotonin	-	Methanosarcina thermophila

Organism

EC Number	Organism	UniProt	Comment	Textmining
4.2.1.1	Methanosarcina thermophila	-	-	-
4.2.1.1	Methanothermobacter thermautotrophicus	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4.2.1.1	CO2 + H2O	-	Methanothermobacter thermautotrophicus	H2CO3	-	r
4.2.1.1	CO2 + H2O	-	Methanosarcina thermophila	H2CO3	-	r

Synonyms

EC Number	Synonyms	Comment	Organism
4.2.1.1	beta-class carbonic anhydrase	-	Methanothermobacter thermautotrophicus
4.2.1.1	Cab	-	Methanothermobacter thermautotrophicus
4.2.1.1	Cam	-	Methanosarcina thermophila
4.2.1.1	gamma-class carbonic anhydrase	-	Methanosarcina thermophila