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Literature summary extracted from
- Inhibitors of anthrax lethal factor based upon N-oleoyldopamine (2008), Bioorg. Med. Chem. Lett., 18, 2467-2470.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.83 | (9Z)-N-(3,4-dihydroxybenzyl)octadec-9-enamide | - |
Bacillus anthracis |  |
| 3.4.24.83 | (9Z)-N-[2-(3,4-dihydroxyphenyl)ethyl]octadec-9-enamide | - |
Bacillus anthracis | |
| 3.4.24.83 | N-hydroxy-4-[[(9Z)-octadec-9-enoylamino]methyl]benzamide | - |
Bacillus anthracis | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.83 | Bacillus anthracis | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.83 | mitogen activated protein kinase kinase + H2O | - |
Bacillus anthracis | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.24.83 | lethal factor | - |
Bacillus anthracis |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.83 | 25 | - |
assay at | Bacillus anthracis |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.83 | 7.4 | - |
assay at | Bacillus anthracis |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.24.83 | 0.0022 | - |
(9Z)-N-(3,4-dihydroxybenzyl)octadec-9-enamide | - |
Bacillus anthracis | |
| 3.4.24.83 | 0.003 | - |
(9Z)-N-[2-(3,4-dihydroxyphenyl)ethyl]octadec-9-enamide | - |
Bacillus anthracis | |
| 3.4.24.83 | 0.0062 | - |
N-hydroxy-4-[[(9Z)-octadec-9-enoylamino]methyl]benzamide | - |
Bacillus anthracis | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.4.24.83 | 0.015 | - |
- |
Bacillus anthracis | (9Z)-N-(3,4-dihydroxybenzyl)octadec-9-enamide | |
| 3.4.24.83 | 0.015 | - |
- |
Bacillus anthracis | (9Z)-N-[2-(3,4-dihydroxyphenyl)ethyl]octadec-9-enamide | |
| 3.4.24.83 | 0.042 | - |
- |
Bacillus anthracis | N-hydroxy-4-[[(9Z)-octadec-9-enoylamino]methyl]benzamide | |
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Release 2023.1 (January 2023)
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