Any feedback?
Literature summary extracted from
- New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity (2008), Bioorg. Med. Chem. Lett., 18, 1893-1897.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.5.1.98 | medicine | HDAC inhibitors are a promising class of anticancer agents | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.1.98 | 2-[(methylsulfonyl)sulfanyl]ethanaminium bromide | - |
Homo sapiens |  |
| 3.5.1.98 | 2-[(methylsulfonyl)sulfanyl]ethyl 2-propylpentanoate | - |
Homo sapiens | |
| 3.5.1.98 | 4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl 2-propylpentanoate | - |
Homo sapiens | |
| 3.5.1.98 | 5-(4-hydroxyphenyl)-3H-1,2-dithiol-3-thione | - |
Homo sapiens | |
| 3.5.1.98 | Butyric acid | - |
Homo sapiens | |
| 3.5.1.98 | S-(2-hydroxyethyl) methanesulfonothioate | - |
Homo sapiens | |
| 3.5.1.98 | S-[2-[(2-propylpentanoyl)amino]ethyl]methanesulfonothioate | - |
Homo sapiens | |
| 3.5.1.98 | Valproic acid | - |
Homo sapiens | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.1.98 | Zn2+ | - |
Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.5.1.98 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.5.1.98 | A-549 cell | - |
Homo sapiens | - |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.5.1.98 | HDAC | - |
Homo sapiens |
| 3.5.1.98 | histone deacetylase | - |
Homo sapiens |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.5.1.98 | 0.00045 | - |
ADTOH | Homo sapiens | 5-(4-hydroxyphenyl)-3H-1,2-dithiol-3-thione | |
| 3.5.1.98 | 0.0096 | - |
- |
Homo sapiens | 2-[(methylsulfonyl)sulfanyl]ethyl 2-propylpentanoate | |
| 3.5.1.98 | 0.0175 | - |
- |
Homo sapiens | S-[2-[(2-propylpentanoyl)amino]ethyl]methanesulfonothioate | |
| 3.5.1.98 | 0.0564 | - |
- |
Homo sapiens | 4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl 2-propylpentanoate | |
| 3.5.1.98 | 0.102 | - |
- |
Homo sapiens | S-(2-hydroxyethyl) methanesulfonothioate | |
| 3.5.1.98 | 0.198 | - |
- |
Homo sapiens | 2-[(methylsulfonyl)sulfanyl]ethanaminium bromide | |
| 3.5.1.98 | 0.995 | - |
- |
Homo sapiens | Valproic acid | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
