EC Number | Cloned (Comment) | Organism |
---|---|---|
1.1.1.21 | expressed in Escherichia coli BL21 (DE3) cells | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.21 | butein | 89.9% inhibition at 0.002 mM | Homo sapiens | |
1.1.1.21 | epalrestat | 85.8% inhibition at 0.0025 mM | Homo sapiens | |
1.1.1.21 | fisetin | 31.1% inhibition at 0.002 mM | Homo sapiens | |
1.1.1.21 | fustin | 20.1% inhibition at 0.002 mM | Homo sapiens | |
1.1.1.21 | Morin hydrate | 14.1% inhibition at 0.002 mM | Homo sapiens | |
1.1.1.21 | pentagalloyl glucose | 46.6% inhibition at 0.002 mM | Homo sapiens | |
1.1.1.21 | protocatechuic acid | 12.6% inhibition at 0.002 mM | Homo sapiens | |
1.1.1.21 | quercetin | 39.1% inhibition at 0.002 mM | Homo sapiens | |
1.1.1.21 | sulfuretin | 69.8% inhibition at 0.002 mM | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.21 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.1.1.21 | Ni-NTA resin column chromatography | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.21 | DL-glyceraldehyde + NADPH + H+ | - |
Homo sapiens | glycerol + NADP+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.21 | alditol/NADP+ oxidoreductase | - |
Homo sapiens |
1.1.1.21 | aldose reductase | - |
Homo sapiens |
1.1.1.21 | ALR2 | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.21 | NADPH | - |
Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.1.1.21 | 0.0007 | - |
in 0.1 M sodium phosphate buffer (pH 6.2) | Homo sapiens | butein | |
1.1.1.21 | 0.0013 | - |
in 0.1 M sodium phosphate buffer (pH 6.2) | Homo sapiens | epalrestat | |
1.1.1.21 | 0.0013 | - |
in 0.1 M sodium phosphate buffer (pH 6.2) | Homo sapiens | sulfuretin |