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Literature summary extracted from

  • Smalley, J.W.; Birss, A.J.; Szmigielski, B.; Potempa, J.
    Mechanism of methaemoglobin breakdown by the lysine-specific gingipain of the periodontal pathogen Porphyromonas gingivalis (2008), Biol. Chem., 389, 1235-1238.
    View publication on PubMedView publication on EuropePMC

General Stability

EC Number General Stability Organism
3.4.22.47 Kgp shows a loss of only 1% and 8% of initial activity after 7 and 24 h, respectively Porphyromonas gingivalis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.47 methemoglobin + H2O Porphyromonas gingivalis degradation, ligation of methemoglobin with N3-, which effectively blocks heme dissociation from the protein, prevents hemoglobin breakdown ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.47 Porphyromonas gingivalis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.47 methemoglobin + H2O degradation, ligation of methemoglobin with N3-, which effectively blocks heme dissociation from the protein, prevents hemoglobin breakdown Porphyromonas gingivalis ?
-
 ?
3.4.22.47 methemoglobin + H2O from horse, degradation, no activity with oxyhemoglobin Porphyromonas gingivalis ?
-
 ?
3.4.22.47 Nalpha-acetyl-L-lysine 4-nitroanilide + H2O
-
 Porphyromonas gingivalis Nalpha-acetyl-L-lysine + 4-nitroaniline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.47 K-gingipain
-
 Porphyromonas gingivalis
3.4.22.47 K-specific gingipain protease
-
 Porphyromonas gingivalis
3.4.22.47 lysine-specific gingipain protease
-
 Porphyromonas gingivalis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.22.47 37
-
 assay at Porphyromonas gingivalis