Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Genis, C.; Sippel, K.H.; Case, N.; Cao, W.; Avvaru, B.S.; Tartaglia, L.J.; Govindasamy, L.; Tu, C.; Agbandje-McKenna, M.; Silverman, D.N.; Rosser, C.J.; McKenna, R.
    Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties (2009), Biochemistry, 48, 1322-1331.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.1 expressed in Escherichia coli BL21(DE3)pLysS cells Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.2.1.1 crystals of carbonic anhydrase II and carbonic anhydrase IX mimic are grown at room temperature using the hanging drop vapour diffusion method Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
4.2.1.1 A65S the mutation can cause variations in binding affinity of small molecule inhibitors Homo sapiens
4.2.1.1 N67Q the mutation can cause variations in binding affinity of small molecule inhibitors Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.1 acetazolamide
-
 Homo sapiens
4.2.1.1 benzolamide
-
 Homo sapiens
4.2.1.1 chlorzolamide potent inhibitor Homo sapiens
4.2.1.1 ethoxzolamide
-
 Homo sapiens
4.2.1.1 methazolamide
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.1 Homo sapiens P00918
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.1 CO2 + H2O
-
 Homo sapiens H2CO3
-
 r

Synonyms

EC Number Synonyms Comment Organism
4.2.1.1 CA II
-
 Homo sapiens
4.2.1.1 CA IX
-
 Homo sapiens
4.2.1.1 carbonic anhydrase II
-
 Homo sapiens
4.2.1.1 carbonic anhydrase IX
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.2.1.1 0.000001
-
 ethoxzolamide Ki less than 0.000001 mM wild type carbonic anhydrase II Homo sapiens
4.2.1.1 0.000001
-
 chlorzolamide wild type carbonic anhydrase IX Homo sapiens
4.2.1.1 0.000002
-
 chlorzolamide wild type carbonic anhydrase II Homo sapiens
4.2.1.1 0.000003
-
 acetazolamide wild type carbonic anhydrase IX Homo sapiens
4.2.1.1 0.000007
-
 benzolamide wild type carbonic anhydrase II Homo sapiens
4.2.1.1 0.000009
-
 methazolamide wild type carbonic anhydrase IX Homo sapiens
4.2.1.1 0.000009
-
 benzolamide wild type carbonic anhydrase IX Homo sapiens
4.2.1.1 0.0000101
-
 acetazolamide wild type carbonic anhydrase II Homo sapiens
4.2.1.1 0.0000118
-
 methazolamide wild type carbonic anhydrase II Homo sapiens