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Literature summary extracted from

  • Artwohl, M.; Lindenmair, A.; Roden, M.; Waldhaeusl, W.K.; Freudenthaler, A.; Klosner, G.; Ilhan, A.; Luger, A.; Baumgartner-Parzer, S.M.
    Fatty acids induce apoptosis in human smooth muscle cells depending on chain length, saturation, and duration of exposure (2009), Atherosclerosis, 202, 351-362.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.22.56 arachidonic acid
-
 Homo sapiens
3.4.22.56 gamma-linolenic-acid
-
 Homo sapiens
3.4.22.56 linoleic acid
-
 Homo sapiens
3.4.22.56 oleic acid
-
 Homo sapiens
3.4.22.56 palmitic acid
-
 Homo sapiens
3.4.22.56 stearic acid
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.61 N-carbobenzyloxy-IETD-fluoromethyl ketone a specific caspase-8 inhibitor Homo sapiens
3.4.22.61 N-carbobenzyloxy-VAD-fluoromethyl ketone a pan-caspase inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.56 additional information Homo sapiens mechanisms of plasma free fatty acid-triggered vascular smooth muscle cell-apoptosis essentially include activation of caspase-3, overview ?
-
 ?
3.4.22.61 additional information Homo sapiens caspase-8 is an initiator caspase. Procaspase-8 activation is essentially involved in apoptosis induced by selected nutritional free fatty acids, mechanisms, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.56 Homo sapiens
-
-
-
3.4.22.61 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.56 vascular smooth muscle cell from umbilical cord Homo sapiens
-
3.4.22.61 smooth muscle
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.56 additional information mechanisms of plasma free fatty acid-triggered vascular smooth muscle cell-apoptosis essentially include activation of caspase-3, overview Homo sapiens ?
-
 ?
3.4.22.61 additional information caspase-8 is an initiator caspase. Procaspase-8 activation is essentially involved in apoptosis induced by selected nutritional free fatty acids, mechanisms, overview Homo sapiens ?
-
 ?